Feinkohl Insa, Borchers Friedrich, Burkhardt Sarah, Krampe Henning, Kraft Antje, Speidel Saya, Kant Ilse M J, van Montfort Simone J T, Aarts Ellen, Kruppa Jochen, Slooter Arjen, Winterer Georg, Pischon Tobias, Spies Claudia
Max-Delbrueck-Center for Molecular Medicine in the Helmholtz Association (MDC), Robert-Roessle-Str. 10, 13092, Berlin, Germany.
Department of Anesthesiology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin and Berlin Institute of Health, Berlin, Germany.
BMC Res Notes. 2020 Feb 4;13(1):55. doi: 10.1186/s13104-020-4919-3.
Studies of postoperative cognitive dysfunction (POCD) rely on repeat neuropsychological testing. The stability of the applied instruments, which are affected by natural variability in performance and measurement imprecision, is often unclear. We determined the stability of a neuropsychological test battery using a sample of older adults from the general population. Forty-five participants aged 65 to 89 years performed six computerized and non-computerized neuropsychological tests at baseline and again at 7 day and 3 months follow-up sessions. Mean scores on each test were compared across time points using repeated measures analyses of variance (ANOVA) with pairwise comparison. Two-way mixed effects, absolute agreement analyses of variance intra-class correlation coefficients (ICC) determined test-retest reliability.
All tests had moderate to excellent test-retest reliability during 7-day (ICC range 0.63 to 0.94; all p < 0.01) and 3-month intervals (ICC range 0.60 to 0.92; all p < 0.01) though confidence intervals of ICC estimates were large throughout. Practice effects apparent at 7 days eased off by 3 months. No substantial differences between computerized and non-computerized tests were observed. We conclude that the present six-test neuropsychological test battery is appropriate for use in POCD research though small sample size of our study needs to be recognized as a limitation. Trial registration ClinicalTrials.gov Identifier NCT02265263 (15th October 2014).
术后认知功能障碍（POCD）的研究依赖于重复的神经心理学测试。所应用工具的稳定性往往不明确，这些工具会受到表现的自然变异性和测量不精确性的影响。我们使用来自普通人群的老年人样本确定了一套神经心理学测试组合的稳定性。45名年龄在65至89岁之间的参与者在基线时以及在随访7天和3个月时分别进行了六项计算机化和非计算机化的神经心理学测试。使用重复测量方差分析（ANOVA）及两两比较对各测试在不同时间点的平均得分进行比较。通过双向混合效应、组内相关系数的绝对一致性方差分析确定重测信度。
在7天（组内相关系数范围为0.63至0.94；所有p<0.01）和3个月的间隔期内（组内相关系数范围为0.60至0.92；所有p<0.01），所有测试均具有中度至极好的重测信度，尽管组内相关系数估计的置信区间在整个过程中都很大。7天时明显的练习效应在3个月时有所缓解。未观察到计算机化测试和非计算机化测试之间存在实质性差异。我们得出结论，目前的六项神经心理学测试组合适用于POCD研究，不过需要认识到我们研究的样本量较小这一局限性。试验注册ClinicalTrials.gov标识符NCT02265263（2014年10月15日）。
