Department of Urology, Antwerp Academic Hospital, Edegem, Belgium; Department of Urology, Faculty of Medicine and Health Sciences, Antwerp University, Wilrijk, Belgium.
Department of Urology, Antwerp Academic Hospital, Edegem, Belgium; Department of Urology, Faculty of Medicine and Health Sciences, Antwerp University, Wilrijk, Belgium.
Eur Urol Focus. 2020 Sep 15;6(5):823-825. doi: 10.1016/j.euf.2019.11.018. Epub 2020 Feb 1.
Although the mechanism of action of sacral neuromodulation (SNM) is still not fully elucidated, it seems to involve modulation of spinal cord reflexes and brain networks by peripheral afferents according to findings from neurophysiology, electroencephalography, positron emission tomography, and magnetic resonance imaging studies. Moreover, motor effects mediated via efferents on direct stimulation cannot be fully excluded. In this mini-review, we summarize current knowledge on the mechanism of action of SNM. PATIENT SUMMARY: We reviewed the literature on the mechanism of action of sacral neuromodulation, in which electrical stimulation is applied to the nerves that regulate bladder activity. The mechanism seems to involve modulation of spinal cord reflexes and brain networks by peripheral sensory and possibly motor neurons.
尽管骶神经调节（SNM）的作用机制尚不完全清楚，但根据神经生理学、脑电图、正电子发射断层扫描和磁共振成像研究的结果，它似乎涉及外周传入对脊髓反射和大脑网络的调节。此外，通过直接刺激的传出介导的运动效应也不能完全排除。在这篇迷你综述中，我们总结了目前关于 SNM 作用机制的知识。
我们回顾了关于骶神经调节作用机制的文献，其中对调节膀胱活动的神经施加电刺激。该机制似乎涉及外周感觉和可能运动神经元对脊髓反射和大脑网络的调节。
