Division of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, University of California San Francisco, San Francisco, CA, USA.
School of Medicine, University of Copenhagen, Copenhagen, Denmark.
J Hum Hypertens. 2020 Nov;34(11):795-801. doi: 10.1038/s41371-020-0306-8. Epub 2020 Feb 4.
Early life prevention of obesity and associated metabolic disease is necessary to address the current obesity epidemic. Latino children have a higher risk of obesity, and associated comorbidities such as hypertension than Caucasian children. This study focuses on perinatal childhood and maternal risk factors associated with prehypertension and hypertension prior to age 9 in an urban Latino cohort. A cohort of low income, US born Latino children (n = 131) in San Francisco was followed from birth. Annual assessments were conducted including child dietary intake, anthropometrics, and blood pressure measurements. Maternal body mass index and depressive symptoms were assessed concurrently. Leukocyte telomere length was assessed at age 4 and 5 in children. Rapid infant weight gain (odds ratio (OR) 7.25, 95% confidence interval (CI) 1.33-39.38) and prenatal maternal clinical depression (OR 6.70 95% CI 1.15-39.16) were associated with prehypertension/hypertension before age 9. Early life obesity and leukocyte telomere length were not associated with childhood hypertension. Rapid infant weight gain and exposure to prenatal maternal depression are predictive of childhood prehypertension/hypertension before age 9 in low income, US-born Latino children. The perinatal period is an important time point to target for prevention of childhood hypertension.
早期预防肥胖及其相关代谢性疾病对于解决当前肥胖流行问题至关重要。拉丁裔儿童肥胖的风险以及与肥胖相关的合并症（如高血压）高于白种人儿童。本研究专注于城市拉丁裔人群中，与儿童期和围产期相关的母亲风险因素，这些因素与 9 岁以下儿童的高血压前期和高血压有关。在旧金山，对一群低收入、美国出生的拉丁裔儿童（n=131）进行了随访。每年进行一次评估，包括儿童饮食摄入、人体测量学和血压测量。同时评估了母亲的体重指数和抑郁症状。在儿童 4 岁和 5 岁时评估白细胞端粒长度。快速婴儿体重增长（比值比 (OR) 7.25，95%置信区间 (CI) 1.33-39.38）和产前母亲临床抑郁（OR 6.70，95% CI 1.15-39.16）与 9 岁以下的高血压前期/高血压有关。儿童期肥胖和白细胞端粒长度与儿童期高血压无关。快速婴儿体重增长和产前母亲抑郁暴露是导致低收入、美国出生的拉丁裔儿童 9 岁以下高血压前期/高血压的预测因素。围产期是预防儿童期高血压的重要时间点。
