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在一项针对患有高血压前期和高血压的儿童及青少年的社区超重与肥胖治疗过程中血压的降低情况。

Reductions in blood pressure during a community-based overweight and obesity treatment in children and adolescents with prehypertension and hypertension.

作者信息

Mollerup P M, Lausten-Thomsen U, Fonvig C E, Baker J L, Holm J-C

机构信息

The Children's Obesity Clinic, Department of Pediatrics, Copenhagen University Hospital Holbæk, Holbæk, Denmark.

Section of Metabolic Genetics, The Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, University of Copenhagen, Copenhagen, Denmark.

出版信息

J Hum Hypertens. 2017 Oct;31(10):640-646. doi: 10.1038/jhh.2017.36. Epub 2017 May 11.

Abstract

Due to the pandemic of childhood obesity and thus obesity-related hypertension, improvements in treatment availability are needed. Hence, we investigated whether reductions in blood pressure (BP) would occur in children with overweight and obesity exhibiting prehypertension/hypertension during a community-based overweight and obesity treatment program, and if changes in body mass index (BMI) are associated with changes in BP. The study included 663 children aged 3-18 years with a BMI ⩾85th percentile for sex and age that entered treatment from June 2012 to January 2015. Height, weight and BP were measured upon entry and every 3-6 months. BMI and BP s.d. scores (SDSs) were calculated according to sex and age, or sex, age and height. Prehypertension was defined as a BP SDS ⩾1.28 and <1.65. Hypertension was defined as a BP SDS ⩾1.65. Upon entry, 52% exhibited prehypertension (11.9%) or exhibited hypertension (40.1%). After 12 months (range: 3-29) of treatment, 29.3% of the children with prehypertension/hypertension were normotensive. Children with systolic prehypertension/hypertension upon entry reduced their systolic BP SDSs by 0.31 (95% confidence interval (CI): 0.70-0.83, P<0.0001). Children with diastolic prehypertension/hypertension upon entry reduced their diastolic BP SDSs by 0.78 (95% CI: 0.78-0.86, P<0.0001). BMI SDS changes were positively associated with BP SDS changes (P<0.0001). Nonetheless, some children reduced BP SDSs while increasing their BMI SDSs, and prehypertension/hypertension developed in 23.3% of the normotensive children despite reductions in BMI SDSs (P<0.0001). These results suggest that community-based overweight and obesity treatment can reduce BP, and thus may help improve treatment availability.

摘要

由于儿童肥胖症以及与之相关的肥胖相关性高血压的流行,因此需要提高治疗的可及性。为此,我们调查了在一个基于社区的超重和肥胖治疗项目中,患有高血压前期/高血压的超重和肥胖儿童的血压(BP)是否会降低,以及体重指数(BMI)的变化是否与血压变化相关。该研究纳入了663名3至18岁的儿童,他们的BMI在2012年6月至2015年1月期间进入治疗时按性别和年龄处于第85百分位数及以上。在入组时以及每3至6个月测量身高、体重和血压。根据性别和年龄,或性别、年龄和身高计算BMI和血压标准差评分(SDSs)。高血压前期定义为血压SDS≥1.28且<1.65。高血压定义为血压SDS≥1.65。入组时,52%的儿童患有高血压前期(11.9%)或高血压(40.1%)。经过12个月(范围:3至29个月)的治疗后,29.3%的高血压前期/高血压儿童血压正常。入组时患有收缩期高血压前期/高血压的儿童,其收缩压SDS降低了0.31(95%置信区间(CI):0.70至0.83,P<0.0001)。入组时患有舒张期高血压前期/高血压的儿童,其舒张压SDS降低了0.78(95%CI:0.78至0.86,P<0.0001)。BMI SDS变化与血压SDS变化呈正相关(P<0.0001)。尽管如此,一些儿童在血压SDS降低的同时BMI SDS却升高了,并且尽管BMI SDS降低,但仍有23.3%的血压正常儿童出现了高血压前期/高血压(P<0.0001)。这些结果表明,基于社区的超重和肥胖治疗可以降低血压,因此可能有助于提高治疗的可及性。

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