Douste-Blazy P, Ruidavets J B, Arveiler D, Bingham A, Camaré R, Schaffer P, Aby M A, Richard J L
Registre Haute-Garonne des cardiopathies ischémiques, INSERM Unité 101-ORSMIP-Toulouse-France.
Acta Med Scand Suppl. 1988;728:137-43. doi: 10.1111/j.0954-6820.1988.tb05565.x.
Cardiovascular risk factors were studied from 1985 to 1987 in population samples in two French regions with different ischaemic heart disease mortality rates in Bas-Rhin (Strasbourg MONICA centre) and in Haute-Garonne (Toulouse MONICA centre). These rates were, among men, 109/100,000 in Bas-Rhin, and 72/100,000 in Haute-Garonne. 1,253 and 1,319 men and women aged 35-64 participated in the survey. In each region, identical investigation methodology was used, according to MONICA protocol. The average weight in both sexes was higher in Bas-Rhin than in Haute-Garonne (5 Kg more for men and 6 Kg more for women). After adjustment for age, body mass index and tobacco consumption, arterial systolic blood pressure was higher for men in Bas-Rhin (145 mm Hg) than in Haute-Garonne (133 mm Hg). Similar differences were observed in women. Higher proportions of hypertensive participants of both sexes and in all age groups were registered in Bas-Rhin than in Haute-Garonne. The number of smokers and the amount of tobacco consumption did not differ between the two centres. Mean serum cholesterol was higher in Haute Garonne (5.95 mmol/L for men and 5.88 mmol/L for women) than in Bas-Rhin (5.57 mmol/L for men and 5.51 mmol/L for women). Also high-density lipoprotein (HDL)-cholesterol values were higher in Haute-Garonne, and can partly explain the regional difference in total cholesterol.
1985年至1987年期间，在法国两个地区的人群样本中对心血管危险因素进行了研究，这两个地区分别是下莱茵省（斯特拉斯堡莫妮卡中心）和上加龙省（图卢兹莫妮卡中心），它们的缺血性心脏病死亡率不同。在男性中，下莱茵省的死亡率为109/10万，上加龙省为72/10万。1253名和1319名年龄在35至64岁之间的男性和女性参与了调查。根据莫妮卡方案，在每个地区都采用了相同的调查方法。下莱茵省男女的平均体重均高于上加龙省（男性高5千克，女性高6千克）。在对年龄、体重指数和烟草消费进行调整后，下莱茵省男性的动脉收缩压（145毫米汞柱）高于上加龙省（133毫米汞柱）。女性中也观察到了类似差异。下莱茵省各年龄组的男女高血压参与者比例均高于上加龙省。两个中心的吸烟者数量和烟草消费量没有差异。上加龙省的平均血清胆固醇水平高于下莱茵省（男性为5.95毫摩尔/升，女性为5.88毫摩尔/升，而下莱茵省男性为5.57毫摩尔/升，女性为5.51毫摩尔/升）。此外，上加龙省的高密度脂蛋白（HDL）胆固醇值也更高，这可以部分解释总胆固醇的地区差异。
