Surgical, Medical and Dental Department of Morphological Sciences, Section of Nephrology, University Hospital of Modena and Reggio Emilia, via del Pozzo, 71, 41124, Modena, Italy.
Nephrology Dialysis and Transplant Unit, University Hospital of Modena, Modena, Italy.
J Nephrol. 2020 Aug;33(4):699-713. doi: 10.1007/s40620-020-00701-8. Epub 2020 Feb 4.
CKD and HIV infection are two chronic diseases impacting heavily on the survival of the affected patients. The interplay between HIV infection and chronic kidney disease (CKD) is complex and interactions occur at multiple levels. Approach to the management of HIV-infected patients requires special attention to face the numerous therapeutic difficulties ranging from drug-drug interactions to drug-toxicity. The most effective strategy is targeted to suppression of HIV viral load, as it dramatically changes the prognosis of the patients as well as prevents the development of HIV-associated kidney disease. As shown in this review, the approach to the therapeutic management of CKD in the setting of HIV infection varies in relation to the degree of renal impairment.
慢性肾脏病（CKD）和 HIV 感染是两种严重影响患者生存的慢性疾病。HIV 感染和慢性肾脏病（CKD）之间的相互作用非常复杂，在多个层面上发生。治疗 HIV 感染患者的方法需要特别注意，以应对从药物相互作用到药物毒性等诸多治疗困难。最有效的策略是针对 HIV 病毒载量的抑制，因为它可以极大地改变患者的预后，并预防 HIV 相关肾脏疾病的发生。正如本综述所示，在 HIV 感染背景下，CKD 的治疗管理方法因肾功能损害的程度而异。
