Lloyd-Edwards Ralph A, Willems Dorien S, Beukers Martijn, van den Brom-Spierenburg Astrid, Vernooij Johannes C M, Veraa Stefanie
Division of Diagnostic Imaging, Faculty of Veterinary Medicine, Utrecht, The Netherlands.
Department of Equine Health, Faculty of Veterinary Medicine, Utrecht, The Netherlands.
Vet Radiol Ultrasound. 2020 May;61(3):269-278. doi: 10.1111/vru.12847. Epub 2020 Feb 5.
Cholesterinic granulomas are mass-like lesions that form at the choroid plexus of the ventricular system. Large cholesterinic granulomas within the lateral ventricles have been reported to cause severe neurological signs. However, little data are available about their prevalence or appearance in the overall population. The objective was to report the prevalence of presumed cholesterinic granulomas on CT in a population of horses, and investigate associations between presumed cholesterinic granuloma presence, lateral ventricle size, age, and neurological signs. The study was cross sectional, CT scans of the head were assessed for presumed cholesterinic granuloma presence and size, and lateral ventricle height. Computed tomography findings and clinical information were compared using nonparametric testing. Computed tomography scans of 139 horses were included. Presumed cholesterinic granulomas were found in 22 horses (15.8%), nine were unilateral and 13 bilateral. A significant increase in prevalence was observed with age (P < .0001), with 38% of horses over 15 years old affected. The median volume of presumed cholesterinic granulomas was 242 mm with a range from 51 to 2420 mm . The mean lateral ventricle height was significantly increased in horses with presumed cholesterinic granulomas present (P = .004), with a median of 7.3 mm compared to 4.9 mm without. Neurological signs were not associated with presumed cholesterinic granuloma presence or lateral ventricle height. Fourth ventricle mineralizations were found in seven horses, which may represent cholesterinic granulomas. In conclusion, presumed cholesterinic granulomas occurred in a large proportion of the examined population and are associated with increased lateral ventricle dilation and advanced age.
胆固醇肉芽肿是在脑室系统脉络丛形成的肿块样病变。据报道，侧脑室内的大型胆固醇肉芽肿会引起严重的神经症状。然而，关于它们在总体人群中的患病率或表现的数据很少。目的是报告马匹群体中CT上推测的胆固醇肉芽肿的患病率，并研究推测的胆固醇肉芽肿的存在、侧脑室大小、年龄和神经症状之间的关联。该研究为横断面研究，对头CT扫描评估推测的胆固醇肉芽肿的存在和大小以及侧脑室高度。使用非参数检验比较CT结果和临床信息。纳入了139匹马的CT扫描。在22匹马（15.8%）中发现了推测的胆固醇肉芽肿，9例为单侧，13例为双侧。随着年龄的增长，患病率显著增加（P <.0001），15岁以上的马匹中有38%受到影响。推测的胆固醇肉芽肿的中位体积为242立方毫米，范围为51至2420立方毫米。存在推测的胆固醇肉芽肿的马匹的平均侧脑室高度显著增加（P = 0.004），中位值为7.3毫米，而无肉芽肿的马匹为4.9毫米。神经症状与推测的胆固醇肉芽肿的存在或侧脑室高度无关。在7匹马中发现了第四脑室矿化，这可能代表胆固醇肉芽肿。总之，推测的胆固醇肉芽肿在很大一部分受检群体中出现，并且与侧脑室扩张增加和年龄增长有关。
