Key Laboratory of Resources Biology and Biotechnology in Western China, Ministry of Education, College of Life Sciences, Northwest University, Xi'an, China.
Department of Anesthesiology, Duke University Medical Center, Durham, North Carolina, USA.
Bosn J Basic Med Sci. 2020 Aug 3;20(3):310-318. doi: 10.17305/bjbms.2020.4597.
Nowadays, the emergence of multidrug-resistant bacterial strains initiates the urgent need for the elucidation of the new drug targets for the discovery of antimicrobial drugs. Filamenting temperature-sensitive mutant Z (FtsZ), a eukaryotic tubulin homolog, is a GTP-dependent prokaryotic cytoskeletal protein and is conserved among most bacterial strains. In vitro studies revealed that FtsZ self-assembles into dynamic protofilaments or bundles and forms a dynamic Z-ring at the center of the cell in vivo, leading to septation and consequent cell division. Speculations on the ability of FtsZ in the blockage of cell division make FtsZ a highly attractive target for developing novel antibiotics. Researchers have been working on synthetic molecules and natural products as inhibitors of FtsZ. Accumulating data suggest that FtsZ may provide the platform for the development of novel antibiotics. In this review, we summarize recent advances in the properties of FtsZ protein and bacterial cell division, as well as in the development of FtsZ inhibitors.
如今，多药耐药菌株的出现促使人们迫切需要阐明新的药物靶点，以发现抗菌药物。丝状温度敏感突变体 Z（FtsZ）是一种真核微管同源物，是一种 GTP 依赖性原核细胞骨架蛋白，在大多数细菌菌株中都保守。体外研究表明，FtsZ 自身组装成动态原纤维或束，并在体内形成位于细胞中心的动态 Z 环，导致分隔和随后的细胞分裂。关于 FtsZ 在阻止细胞分裂方面的能力的推测使 FtsZ 成为开发新型抗生素的极具吸引力的靶标。研究人员一直在研究合成分子和天然产物作为 FtsZ 的抑制剂。越来越多的证据表明，FtsZ 可能为开发新型抗生素提供平台。在这篇综述中，我们总结了 FtsZ 蛋白和细菌细胞分裂的特性以及 FtsZ 抑制剂的最新进展。
