Foote Kimberley, Gilroy Cornelia, Burton Shelley, Horney Barbara, Lopez Alfonso, Savidge Christine, Goff Tamara
Pathology and Microbiology (Foote, Gilroy, Burton, Horney, Lopez) and Companion Animal Departments (Savidge), Atlantic Veterinary College, University of Prince Edward Island, 550 University Avenue, Charlottetown, Prince Edward Island C1A 4P3; Cornwall Veterinary Clinic, 375 Trans-Canada Highway, Cornwall, Prince Edward Island C0A 1H0 (Goff ).
Can Vet J. 2020 Feb;61(2):147-152.
Two cases of canine zinc toxicosis with pancreatic disease are reported. Both dogs had pigmenturia, pallor, regenerative anemia, an inflammatory leukogram, hyperbilirubinemia, hyperamylasemia, and hyperlipasemia. Zinc toxicosis was diagnosed post-mortem in patient 1 based on the discovery of a metallic gastric foreign object, pancreatic necrosis, nephrosis, and high tissue zinc concentrations. Survey radiographs of patient 2 allowed identification and prompt removal of coins from the stomach with resolution of anemia, hyperamylasemia, and hyperlipasemia 3 days post-gastroscopy. Plasma zinc concentration was markedly elevated in patient 2. Zinc toxicosis should be considered in dogs with concurrent hemolytic anemia and pancreatic disease.
报告了两例伴有胰腺疾病的犬锌中毒病例。两只犬均有色素尿、苍白、再生性贫血、炎症性白细胞计数、高胆红素血症、高淀粉酶血症和高脂肪酶血症。病例1在死后诊断为锌中毒，依据是发现金属性胃内异物、胰腺坏死、肾病以及高组织锌浓度。病例2的X线平片检查使得能够识别并及时从胃中取出硬币，胃镜检查3天后贫血、高淀粉酶血症和高脂肪酶血症得到缓解。病例2的血浆锌浓度显著升高。对于并发溶血性贫血和胰腺疾病的犬，应考虑锌中毒。
