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沸石纳米粒子在生物医学中的应用，重点是医学干预。

Biomedical Applications of Zeolitic Nanoparticles, with an Emphasis on Medical Interventions.

机构信息

Pharmaceutical Sciences Research Center, Health Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran.

Zistmavad Pharmed Co., Tehran, Iran.

出版信息

Int J Nanomedicine. 2020 Jan 21;15:363-386. doi: 10.2147/IJN.S234573. eCollection 2020.

DOI:10.2147/IJN.S234573
PMID:32021185
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6983480/
Abstract

The advent of porous materials, in particular zeolitic nanoparticles, has opened up unprecedented putative research avenues in nanomedicine. Zeolites with intracrystal mesopores are low framework density aluminosilicates possessing a regular porous structure along with intricate channels. Their unique physiochemical as well as physiological parameters necessitate a comprehensive overview on their classifications, fabrication platforms, cellular/macromolecular interactions, and eventually their prospective biomedical applications through illustrating the challenges and opportunities in different integrative medical and pharmaceutical fields. More particularly, an update on recent advances in zeolite-accommodated drug delivery and the prevalent challenges regarding these molecular sieves is to be presented. In conclusion, strategies to accelerate the translation of these porous materials from bench to bedside along with common overlooked physiological and pharmacological factors of zeolite nanoparticles are discussed and debated. Furthermore, for zeolite nanoparticles, it is a matter of crucial importance, in terms of biosafety and nanotoxicology, to appreciate the zeolite-bio interface once the zeolite nanoparticles are exposed to the bio-macromolecules in biological media. We specifically shed light on interactions of zeolite nanoparticles with fibrinogen and amyloid beta which had been comprehensively investigated in our recent reports. Given the significance of zeolite nanoparticles' interactions with serum or interstitial proteins conferring them new biological identity, the preliminary approaches for deeper understanding of administration, distribution, metabolism and excretion of zeolite nanoparticles are elucidated.

摘要

多孔材料的出现，特别是沸石纳米粒子，为纳米医学开辟了前所未有的潜在研究途径。具有晶体中介孔的沸石是低骨架密度的铝硅酸盐，具有规则的多孔结构和复杂的通道。它们独特的物理化学和生理参数需要对它们的分类、制造平台、细胞/大分子相互作用进行全面概述，最终通过阐明不同综合医学和制药领域的挑战和机遇，展示它们在生物医学中的应用前景。更具体地说，将介绍沸石容纳药物输送方面的最新进展以及这些分子筛目前存在的挑战。总之，讨论和辩论了加速这些多孔材料从实验室到临床的转化的策略，以及沸石纳米粒子常见的被忽视的生理和药理学因素。此外，就生物安全性和纳米毒理学而言，对于沸石纳米粒子而言，至关重要的是一旦沸石纳米粒子暴露于生物介质中的生物大分子，就要了解沸石-生物界面。我们特别关注了沸石纳米粒子与纤维蛋白原和淀粉样β的相互作用，这在我们最近的报告中得到了全面研究。鉴于沸石纳米粒子与血清或间质蛋白相互作用赋予它们新的生物学特性的重要性，阐述了更深入了解沸石纳米粒子的给药、分布、代谢和排泄的初步方法。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b9a3/6983480/32f4d5052a6f/IJN-15-363-g0011.jpg
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