Laboratory of Controllable Preparation and Application of Nanomaterials, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing, 100190, China.
CAS Key Laboratory of Cryogenics, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing, 100190, China.
Small Methods. 2024 Mar;8(3):e2301270. doi: 10.1002/smtd.202301270. Epub 2023 Nov 23.
Zeolite imidazole framework-8 (ZIF-8) is the most prestigious one among zeolitic imidazolate framework (ZIF) with tunable dimensions and unique morphological features. Utilizing its synthetic adjustability and structural regularity, ZIF-8 exhibits enhanced flexibility, allowing for a wide range of functionalities, such as loading of nanoparticle components while preserving biomolecules activity. Extensive efforts are made from investigating synthesis techniques to develop novel applications over decades. In this review, the development and recent progress of various synthesis approaches are briefly summarized. In addition, its interesting properties such as adjustable porosity, excellent thermal, and chemical stabilities are introduced. Further, five representative biomedical applications are highlighted based on above physicochemical properties. Finally, the remaining challenges and offered insights into the future outlook are also discussed. This review aims to understand the co-relationships between structures and biomedical functionalities, offering the opportunity to construct attractive materials with promising characteristics.
沸石咪唑骨架-8（ZIF-8）是沸石咪唑骨架（ZIF）中最负盛名的一种，具有可调节的尺寸和独特的形态特征。利用其合成的可调节性和结构规则性，ZIF-8 表现出增强的灵活性，允许多种功能，如负载纳米颗粒成分，同时保持生物分子的活性。几十年来，人们一直在努力研究合成技术，以开发新的应用。在这篇综述中，简要总结了各种合成方法的发展和最新进展。此外，还介绍了其有趣的性质，如可调孔隙率、优异的热稳定性和化学稳定性。此外，基于上述物理化学性质，重点介绍了五种有代表性的生物医学应用。最后，还讨论了剩余的挑战和对未来展望的见解。本文综述旨在了解结构和生物医学功能之间的关系，为构建具有有吸引力的特性的材料提供机会。
