Welch I M, Davison P A, Worlding J, Read N W
Sub-Department of Human Gastrointestinal Physiology and Nutrition, University of Sheffield, Royal Hallamshire Hospital, United Kingdom.
Am J Physiol. 1988 Dec;255(6 Pt 1):G800-6. doi: 10.1152/ajpgi.1988.255.6.G800.
To investigate how ileal lipid delays small bowel transit, pressure activity was recorded at multiple sites in the human small intestine during ileal infusion of either lipid or saline. Initial studies showed that ileal lipid reduced the contraction rate in the jejunum but not in the duodenum or ileum. The effect of ileal lipid was further investigated by recording pressures at seven sites in the jejunum after ingestion of either a nutrient or a nonnutrient meal. The nutrient meal induced an irregular motility pattern; ileal lipid significantly reduced the contraction rate, the percentage of contractions involved in propagated events, the mean length of propagation, and the propagation index. The nonnutrient meal induced a pattern containing discrete clusters of contractions. Ileal lipid significantly reduced the occurrence of contraction clusters and the mean length of propagation. Thus, although the delay in small bowel transit observed during ileal infusion of lipid can be explained by reductions in the rate and the degree of propagation of jejunal contractions, the mechanism varies according to the type of meal.
为了研究回肠脂质如何延迟小肠转运，在回肠输注脂质或生理盐水期间，记录了人体小肠多个部位的压力活动。初步研究表明，回肠脂质降低了空肠的收缩率，但对十二指肠或回肠没有影响。通过记录摄入营养性或非营养性餐后空肠七个部位的压力，进一步研究了回肠脂质的作用。营养性餐诱导出不规则的运动模式；回肠脂质显著降低了收缩率、参与传播事件的收缩百分比、平均传播长度和传播指数。非营养性餐诱导出一种包含离散收缩簇的模式。回肠脂质显著降低了收缩簇的发生率和平均传播长度。因此，尽管在回肠输注脂质期间观察到的小肠转运延迟可以通过空肠收缩率和传播程度的降低来解释，但其机制因餐的类型而异。
