Wood J G, Hoang H D, Bussjaeger L J, Solomon T E
Department of Medicine, Kansas University Medical Center, Kansas City 66102.
Am J Physiol. 1988 Dec;255(6 Pt 1):G813-7. doi: 10.1152/ajpgi.1988.255.6.G813.
Neurotensin has many actions on digestive tract motility and secretion and stimulates pancreatic growth. We examined effects of chronic administration of neurotensin on growth of small intestine and colon. Four groups of 10 rats were injected with saline or neurotensin (33, 100, or 300 micrograms/kg) every 8 h for 5 days. The small intestine was divided into four segments of equal length, weighed, and assayed for DNA, protein, and brush-border digestive enzymes. The colon was weighed and assayed for DNA and protein. Neurotensin caused dose-related increases in growth of small intestine; at the highest dose, similar increases in weight (12-20%), DNA (23-35%), and protein content (33-39%) occurred in each segment of small intestine. Maltase, sucrase, and leucine aminopeptidase (but not lactase) contents were also significantly increased after neurotensin, but the largest effects were seen in the proximal small intestine. Neurotensin had no effect on weight, DNA, or protein content of the colon. These results suggest a role for neurotensin in regulating growth of small intestine.
神经降压素对消化道的运动和分泌有多种作用，并能刺激胰腺生长。我们研究了长期给予神经降压素对小肠和结肠生长的影响。将四组每组10只大鼠，每8小时注射一次生理盐水或神经降压素（33、100或300微克/千克），持续5天。将小肠分成四段等长的部分，称重，并检测DNA、蛋白质和刷状缘消化酶。称量结肠重量，并检测其DNA和蛋白质。神经降压素导致小肠生长呈剂量依赖性增加；在最高剂量时，小肠各段的重量（增加12 - 20%）、DNA（增加23 - 35%）和蛋白质含量（增加33 - 39%）均有类似增加。神经降压素处理后，麦芽糖酶、蔗糖酶和亮氨酸氨肽酶（但不包括乳糖酶）的含量也显著增加，但在小肠近端观察到的影响最大。神经降压素对结肠的重量、DNA或蛋白质含量没有影响。这些结果表明神经降压素在调节小肠生长中起作用。
