Gray D A, Erasmus T
Department of Zoology, University of Port Elizabeth, South Africa.
Am J Physiol. 1988 Dec;255(6 Pt 2):R936-9. doi: 10.1152/ajpregu.1988.255.6.R936.
In conscious kelp gulls, intravenous infusion of arginine vasotocin (AVT) at rates of 0.03, 0.1, 0.3, and 1.0 ng.kg-1.min-1 resulted in a linear relationship between the log values of the AVT plasma concentrations (measured by radioimmunoassay) and the infusion rates, which indicated a plasma clearance rate for AVT of 15.4 ml.min-1.kg-1 when endogenous AVT formation is considered. Evaluation of the renal actions of AVT at each dose level showed that antidiuresis was consistently associated with reductions in glomerular filtration rate as well as changes in tubule water permeability. Thus the water-conserving action of plasma AVT on the kelp gull kidney involves contributions from both glomerular and tubular mechanisms over the entire physiological range found in these birds.
在清醒的海带鸥中，以0.03、0.1、0.3和1.0 ng·kg⁻¹·min⁻¹的速率静脉输注精氨酸血管加压素（AVT），导致AVT血浆浓度（通过放射免疫测定法测量）的对数值与输注速率之间呈线性关系，这表明在考虑内源性AVT形成时，AVT的血浆清除率为15.4 ml·min⁻¹·kg⁻¹。对每个剂量水平的AVT肾脏作用进行评估表明，抗利尿作用始终与肾小球滤过率降低以及肾小管水通透性变化相关。因此，血浆AVT对海带鸥肾脏的保水作用涉及这些鸟类整个生理范围内肾小球和肾小管机制的共同作用。
