Bronson R A, Cooper G W
Division of Human Reproduction, North Shore University Hospital, Manhasset, New York.
Am J Reprod Immunol Microbiol. 1988 Sep;18(1):7-10. doi: 10.1111/j.1600-0897.1988.tb00225.x.
Antisperm antibodies of the IgA class, when bound to sperm, impair the sperm's ability to penetrate cervical mucus. IgA proteases offer a potential treatment of autoimmunity to spermatozoa in infertile men by enzymatically degrading immunoglobulins on the sperm surface. As IgA1 but not IgA2 is cleaved by IgA proteases, we determined through use of IgA subclass-specific monoclonal antibodies the presence and relative proportions of antisperm IgA1 and IgA2 in seminal fluid. This ratio varies substantially between men, perhaps reflecting differences in the etiology of autoimmunity to sperm.
IgA类抗精子抗体一旦与精子结合，就会损害精子穿透宫颈黏液的能力。IgA蛋白酶通过酶解精子表面的免疫球蛋白，为治疗不育男性精子自身免疫提供了一种潜在方法。由于IgA蛋白酶可切割IgA1而非IgA2，我们利用IgA亚类特异性单克隆抗体，测定了精液中抗精子IgA1和IgA2的存在情况及相对比例。该比例在男性之间差异很大，这可能反映了精子自身免疫病因的差异。
