Wolff H, Schill W B
Fertil Steril. 1985 Nov;44(5):673-7.
The incidence and significance of antisperm antibodies in different groups of men were evaluated by a modified enzyme-linked immunosorbent assay. In serum, 4.0% of dermatologic patients (n = 223), 9.6% of andrologic patients (n = 178), and 28.6% of homosexual men (n = 42) were positive for IgG and/or IgM antibodies. In seminal fluids, 7.3% of the andrologic patients had IgA (and IgG) antibodies to spermatozoa. Only 1 of 29 positive men had antibodies both in serum and in seminal fluid. No correlation between antisperm antibodies and IgG/IgM concentrations was found in serum, whereas in seminal plasma men with antisperm antibodies showed higher IgG/IgA concentrations than men without (IgA, 3.2 versus 1.7 mg/dl; IgG, 9.8 versus 6.3 mg/dl). It is concluded that there is a high incidence of antisperm antibodies among homosexual men, probably because of contact of spermatozoa with the immune system by passive anal intercourse. There is little correlation between antisperm antibodies in serum and seminal plasma of infertile men because of a lack of relevant antibody transfer from the serum and the formation of local antibodies in seminal plasma. Antisperm antibodies in seminal fluid are associated with elevated local IgG and IgA concentrations.
采用改良的酶联免疫吸附测定法评估了不同男性群体中抗精子抗体的发生率及其意义。在血清中，皮肤科患者（n = 223）中有4.0%、男科患者（n = 178）中有9.6%以及同性恋男性（n = 42）中有28.6%的IgG和/或IgM抗体呈阳性。在精液中，7.3%的男科患者有针对精子的IgA（和IgG）抗体。29名抗体呈阳性的男性中只有1人血清和精液中均有抗体。血清中未发现抗精子抗体与IgG/IgM浓度之间存在相关性，而在精浆中，有抗精子抗体的男性的IgG/IgA浓度高于无抗精子抗体的男性（IgA，3.2对1.7mg/dl；IgG，9.8对6.3mg/dl）。得出的结论是，同性恋男性中抗精子抗体的发生率很高，这可能是由于被动肛交导致精子与免疫系统接触所致。不育男性血清和精浆中的抗精子抗体之间几乎没有相关性，这是因为血清中缺乏相关抗体转移以及精浆中存在局部抗体形成。精液中的抗精子抗体与局部IgG和IgA浓度升高有关。
