枸橼酸氯米芬给药前后，低促性腺激素性性腺功能减退和青春期延迟患者血清促黄体生成素（LH）对LH释放激素（LH-RH）刺激的差异反应。

Differential response of serum LH in hypogonadotropic hypogonadism and delayed puberty to LH-RH stimulation before and after clomiphene citrate administration.

作者信息

Snoep M C, de Lange W E, Sluiter W J, Doorenbos H

出版信息

J Clin Endocrinol Metab. 1977 Mar;44(3):603-6. doi: 10.1210/jcem-44-3-603.

DOI:10.1210/jcem-44-3-603

Abstract

The differential diagnosis between hypogonadotropic hypogonadism and delayed puberty is facilitated by comparing the response of gonadotropins to LH-RH stimulation before and after administration of clomiphene citrate 200 mg daily during 7 days. Premedication of clomiphene citrate depresses peak values of LH and FSH on LH-RH in delayed puberty. In hypogonadotropic hypogonadism clomiphene citrate raises LH-RH induced peak LH while FSH does not change.

摘要

通过比较在连续7天每天服用200毫克枸橼酸氯米芬前后促性腺激素对促黄体生成素释放激素（LH-RH）刺激的反应，有助于鉴别低促性腺激素性性腺功能减退和青春期延迟。在青春期延迟中，枸橼酸氯米芬预处理会降低LH-RH刺激下促黄体生成素（LH）和促卵泡生成素（FSH）的峰值。在低促性腺激素性性腺功能减退中，枸橼酸氯米芬会提高LH-RH诱导的LH峰值，而FSH则无变化。

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J Endocrinol Invest. 1984 Dec;7(6):611-4. doi: 10.1007/BF03349494.

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