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J Affect Disord. 2020 Jan 1;260:418-425. doi: 10.1016/j.jad.2019.09.065. Epub 2019 Sep 13.
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Influence of age and gender on reference values for common pediatric sleep questionnaires: Results from a community-based study.年龄和性别对常见儿科睡眠问卷参考值的影响：一项基于社区研究的结果。
Int J Pediatr Otorhinolaryngol. 2018 Jun;109:127-132. doi: 10.1016/j.ijporl.2018.04.004. Epub 2018 Apr 9.
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Sleep spindle activity in children with obstructive sleep apnea as a marker of neurocognitive performance: A pilot study.阻塞性睡眠呼吸暂停患儿睡眠纺锤波活动作为神经认知表现的标志物：一项初步研究。
Eur J Paediatr Neurol. 2018 May;22(3):434-439. doi: 10.1016/j.ejpn.2018.02.003. Epub 2018 Feb 9.
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Characterizing sleep spindles in 11,630 individuals from the National Sleep Research Resource.从国家睡眠研究资源中，对 11630 个人的睡眠纺锤波进行特征描述。
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Frequency of snoring, rather than apnea-hypopnea index, predicts both cognitive and behavioral problems in young children.打鼾频率而非呼吸暂停低通气指数可预测幼儿的认知和行为问题。
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Widespread reduction in sleep spindle activity in socially anxious children and adolescents.社交焦虑儿童和青少年睡眠纺锤波活动普遍减少。
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Effect of Sleep-disordered Breathing Severity on Cognitive Performance Measures in a Large Community Cohort of Young School-aged Children.睡眠呼吸障碍严重程度对大型社区学龄儿童队列认知能力测量的影响。
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10
Diagnostic accuracy of the Spanish version of the Pediatric Sleep Questionnaire for screening of obstructive sleep apnea in habitually snoring children.西班牙文版儿童睡眠问卷对习惯性打鼾儿童阻塞性睡眠呼吸暂停筛查的诊断准确性
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睡眠呼吸障碍儿童的睡眠纺锤波活动与嗜睡的关联

Association of sleep spindle activity and sleepiness in children with sleep-disordered breathing.

作者信息

Brockmann Pablo E, Ferri Raffaele, Bruni Oliviero

机构信息

Department of Pediatric Cardiology and Pulmonology, Division of Pediatrics, School of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile.

Pediatric Sleep Center, School of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile.

出版信息

J Clin Sleep Med. 2020 Apr 15;16(4):583-589. doi: 10.5664/jcsm.8282.

DOI:10.5664/jcsm.8282
PMID:32022667
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7161436/
Abstract

STUDY OBJECTIVES

The association of snoring and sleep-disordered breathing (SDB) with daytime sleepiness is well documented; however, the exact mechanisms, and especially the role of sleep microstructure that may account for this association remain incompletely understood. In a cohort of children with SDB, we aimed to compare sleep spindle activity between children with daytime sleepiness versus those without daytime sleepiness.

METHODS

Children with SDB who reported daytime sleepiness were recruited and compared with age- and sex-matched SDB controls. Polysomnographic recordings were analyzed evaluating sleep spindle activity. A statistical comparison was carried out in both groups to assess the association between sleepiness and sleep spindle activity.

RESULTS

Thirty-three children with SDB (mean age: 7.5 ± 1.7 years) were included, 10 with and 23 without daytime sleepiness. Spindle activity was lower in children with daytime sleepiness compared with those without; in stage N2, median (interquartile range) sleep spindle indexes were 77.5 (37.3) and 116.9 (71.2) (P = .015), respectively.

CONCLUSIONS

Spindles were significantly reduced in children with SDB and daytime sleepiness. The exact mechanisms of this association remain unknown and future research is needed in order to establish the exact role of sleep spindle activity on daytime symptoms in children with SDB.

摘要

研究目的

打鼾和睡眠呼吸紊乱（SDB）与日间嗜睡之间的关联已有充分记录；然而，确切机制，尤其是可能解释这种关联的睡眠微观结构的作用仍未完全明了。在一组患有SDB的儿童中，我们旨在比较有日间嗜睡的儿童与无日间嗜睡的儿童之间的睡眠纺锤波活动。

方法

招募报告有日间嗜睡的SDB儿童，并与年龄和性别匹配的SDB对照进行比较。对多导睡眠图记录进行分析以评估睡眠纺锤波活动。在两组中进行统计学比较，以评估嗜睡与睡眠纺锤波活动之间的关联。

结果

纳入33名SDB儿童（平均年龄：7.5±1.7岁），其中10名有日间嗜睡，23名无日间嗜睡。有日间嗜睡的儿童的纺锤波活动低于无日间嗜睡的儿童；在N2期，睡眠纺锤波指数的中位数（四分位间距）分别为77.5（37.3）和116.9（71.2）（P = 0.015）。

结论

患有SDB和日间嗜睡的儿童的纺锤波明显减少。这种关联的确切机制尚不清楚，需要进一步研究以确定睡眠纺锤波活动在患有SDB的儿童日间症状中的确切作用。