Department of Pediatric Cardiology and Pulmonology, Division of Pediatrics, School of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile; Sleep Medicine Center, Department of Neurology, School of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile.
Department of Pediatric Cardiology and Pulmonology, Division of Pediatrics, School of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile.
Eur J Paediatr Neurol. 2018 May;22(3):434-439. doi: 10.1016/j.ejpn.2018.02.003. Epub 2018 Feb 9.
To assess spindle activity as possible markers for neurocognitive consequences in children with mild obstructive sleep apnea.
Children aged 6-11 years diagnosed with mild OSA (i.e., an apnea hypopnea index <5.0) were recruited and compared with age and gender-matched healthy controls. Polysomnographic recordings were analyzed for sleep microstructure and spindle activity. All children completed also an intelligence test battery (i.e., the Wechsler intelligence test for children, 4th version).
Nineteen children with OSA (13 boys, mean age 7.1 ± 1.4 y), and 14 controls (7 boys, mean age 8.1 ± 1.9 y) were included. Mean IQ was 110 ± 12 for the complete sample, in children with OSA 111 ± 13, and in controls 108 ± 12 (p = 0.602). Controls showed a higher spindle index in N2 stage than children with OSA: 143.0 ± 42.5 vs 89.5 ± 56.9, respectively (p = 0.003). Spindle index in NREM was strongly and significantly correlated with Verbal Comprehension Index (VCI), Working Memory Index (WMI), Processing Speed Index (PSI), and total IQ in children with OSA.
Children with mild OSA demonstrate a different pattern of sleep spindle activity that seems to be linked with neurocognitive performance, especially concerning memory. Sleep spindle activity seems to be involved with mechanisms related with neurocognitive consequences in children with OSA.
评估纺锤波活动作为儿童轻度阻塞性睡眠呼吸暂停（obstructive sleep apnea，OSA）神经认知后果的可能标志物。
招募了年龄在 6-11 岁之间被诊断为轻度 OSA（即呼吸暂停低通气指数 <5.0）的儿童，并与年龄和性别匹配的健康对照组进行比较。对多导睡眠图记录进行睡眠微结构和纺锤波活动分析。所有儿童还完成了智力测试（即韦氏儿童智力量表，第四版）。
19 名 OSA 儿童（13 名男孩，平均年龄 7.1±1.4 岁）和 14 名对照组儿童（7 名男孩，平均年龄 8.1±1.9 岁）被纳入研究。所有儿童的平均智商为 110±12，OSA 儿童为 111±13，对照组为 108±12（p=0.602）。对照组在 N2 期的纺锤波指数高于 OSA 儿童：分别为 143.0±42.5 和 89.5±56.9（p=0.003）。OSA 儿童的非快速眼动（NREM）期纺锤波指数与言语理解指数（verbal comprehension index，VCI）、工作记忆指数（working memory index，WMI）、处理速度指数（processing speed index，PSI）和总智商呈强烈和显著相关。
患有轻度 OSA 的儿童表现出不同的睡眠纺锤波活动模式，似乎与神经认知表现相关，特别是与记忆相关。睡眠纺锤波活动似乎与 OSA 儿童的神经认知后果相关的机制有关。
