Van Velthoven Michelle Helena, Milne-Ives Madison, de Cock Caroline, Mooney Mary, Meinert Edward
Digitally Enabled PrevenTative Health (DEPTH) Research Group, Department of Paediatrics, Oxford, United Kingdom.
School of Nursing & Midwifery, Trinity College Dublin, Dublin, Ireland.
JMIR Res Protoc. 2020 Feb 5;9(2):e16929. doi: 10.2196/16929.
The decline in the uptake of routine childhood vaccinations has resulted in outbreaks of vaccine-preventable diseases. Vaccination apps can be used as a tool to promote immunization through the provision of reminders, dissemination of information, peer support, and feedback.
The aim of this review is to systematically review the evidence on the use of apps to support childhood vaccination uptake, information storage, and record sharing.
We will identify relevant papers by searching the following electronic databases: PubMed, Embase by Ovid, Web of Science, Cochrane Central Register of Controlled Trials (CENTRAL), ClinicalTrials.gov, and Education Resources Information Center (ERIC). We will review the reference lists of those studies that we include to identify relevant additional papers not initially identified using our search strategy. In addition to the use of electronic databases, we will search for grey literature on the topic. The search strategy will include only terms relating to or describing the intervention, which is app use. As almost all titles and abstracts are in English, 100% of these will be reviewed, but retrieval will be confined to papers written in the English language. We will record the search outcome on a specifically designed record sheet. Two reviewers will select observational and intervention studies, appraise the quality of the studies, and extract the relevant data. All studies will involve the use of apps relating to child vaccinations. The primary outcome is the uptake of vaccinations. Secondary outcomes are as follows: (1) use of app for sharing of information and providing vaccination reminders and (2) use of app for storage of vaccination information; knowledge and decision making by parents regarding vaccination (ie, risks and benefits of vaccination); costs and cost-effectiveness of vaccination apps; use of the app and measures of usability (eg, usefulness, acceptability, and experiences of different users: parents and health care professionals); use of technical standards for development of the app; and adverse events (eg, data leaks and misinformation). We will exclude studies that do not study an app. We anticipate a limited scope for meta-analysis and will provide a narrative overview of findings and tabular summaries of extracted data.
This project was funded by the Sir David Cooksey Fellowship in Healthcare Translation at the University of Oxford, Oxford, United Kingdom. We will submit the full systematic review for publication in the Journal of Medical Internet Research.
This review will follow, where possible, the Cochrane Collaboration and the Centre for Review and Dissemination methodologies for conducting systematic reviews. We will report our findings based on guidelines from the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement. The review results will be used to inform the development of a vaccination app.
INTERNATIONAL REGISTERED REPORT IDENTIFIER (IRRID): PRR1-10.2196/16929.
儿童常规疫苗接种率的下降导致了疫苗可预防疾病的爆发。疫苗接种应用程序可作为一种工具，通过提供提醒、传播信息、同伴支持和反馈来促进免疫接种。
本综述的目的是系统评价关于使用应用程序支持儿童疫苗接种、信息存储和记录共享的证据。
我们将通过搜索以下电子数据库来识别相关论文：PubMed、Ovid平台的Embase、科学引文索引、Cochrane对照试验中心注册库（CENTRAL）、ClinicalTrials.gov和教育资源信息中心（ERIC）。我们将查阅所纳入研究的参考文献列表，以识别那些最初未通过我们的检索策略识别出的相关额外论文。除了使用电子数据库外，我们还将搜索关于该主题的灰色文献。检索策略将仅包括与干预措施（即应用程序的使用）相关或描述干预措施的术语。由于几乎所有标题和摘要均为英文，因此将对其中100%进行审查，但检索将限于用英文撰写的论文。我们将把检索结果记录在专门设计的记录表格上。两名评审员将选择观察性和干预性研究，评估研究质量，并提取相关数据。所有研究都将涉及使用与儿童疫苗接种相关的应用程序。主要结局是疫苗接种率。次要结局如下：（1）使用应用程序共享信息并提供疫苗接种提醒；（2）使用应用程序存储疫苗接种信息；家长关于疫苗接种的知识和决策（即疫苗接种的风险和益处）；疫苗接种应用程序的成本和成本效益；应用程序的使用情况和可用性指标（例如，有用性、可接受性以及不同用户：家长和医护人员的体验）；应用程序开发所使用的技术标准；以及不良事件（例如，数据泄露和错误信息）。我们将排除不研究应用程序的研究。我们预计荟萃分析的范围有限，并将提供研究结果的叙述性概述和提取数据的表格总结。
该项目由英国牛津大学大卫·库克西爵士医疗保健翻译奖学金资助。我们将提交完整的系统评价以在《医学互联网研究杂志》上发表。
本综述将尽可能遵循Cochrane协作网和综述与传播中心进行系统评价的方法。我们将根据系统评价和荟萃分析的首选报告项目（PRISMA）声明中的指南报告我们的研究结果。综述结果将用于为疫苗接种应用程序的开发提供信息。
国际注册报告识别号（IRRID）：PRR1-10.2196/16929。
