Aronstam A, Kirk P J, McHardy J, Culver-James J W, McLellan D S, Turk P, Rainsford S G, Slattery M
J Clin Pathol. 1977 Jan;30(1):65-7. doi: 10.1136/jcp.30.1.65.
Factor VIII-containing materials were administered to four severely affected haemophiliacs twice weekly in doses calculated to raise the factor VIII level to either 15% or 30% of average normal. The pooled results from those patients with statistically similar baseline bleeding frequencies showed a significant reduction in bleeding frequency on both doses in the first 48 hours. The 30% dose produced a more significant reduction than the 15% dose in the first 24 hours, but there was no significant difference between the two doses in the second 24 hours. It appears that to reduce the bleeding frequency of severely affected haemophiliacs by 60% would require a two-and-a-half-fold increase in therapeutic materials. A 90% reduction would need nine times the amount of material currently in use.
给四名重症血友病患者每周两次注射含凝血因子VIII的材料，剂量按能将凝血因子VIII水平提高到平均正常值的15%或30%来计算。那些基线出血频率在统计学上相似的患者的汇总结果显示，在最初48小时内，两种剂量的出血频率均显著降低。在最初24小时内，30%剂量组的出血频率降低幅度比15%剂量组更显著，但在第二个24小时内，两组剂量之间无显著差异。似乎要将重症血友病患者的出血频率降低60%，治疗材料需要增加2.5倍。要将出血频率降低90%，所需材料量将是目前使用量的9倍。
