Ramsay D M, Parker A C
J Clin Pathol. 1973 Apr;26(4):243-7. doi: 10.1136/jcp.26.4.243.
A trial of prophylactic replacement therapy in low dosage once a week is described in two patients with classical haemophilia and one patient with Christmas disease, using concentrates of factor VIII and factor IX respectively. The clinical effectiveness and complications of the therapy are assessed and discussed. It was concluded that the patient suffering from Christmas disease showed both objective and subjective improvement while on prophylaxis and merited further study. Neither of the patients with haemophilia showed objective evidence of improvement, but both stated that they felt fitter and more able to lead a normal life while on the trial.
描述了对两名典型血友病患者和一名克里斯马斯病患者进行每周一次低剂量预防性替代疗法的试验，分别使用了凝血因子VIII和凝血因子IX浓缩物。对该疗法的临床疗效和并发症进行了评估和讨论。得出的结论是，患有克里斯马斯病的患者在接受预防治疗时，客观和主观上均有改善，值得进一步研究。两名血友病患者均未显示出客观的改善证据，但两人均表示在试验期间感觉更健康，更有能力过上正常生活。
