Human Performance Laboratory, Department of Kinesiology and Health Education, University of Texas at Austin, Austin, TX, United States of America.
PLoS One. 2020 Feb 5;15(2):e0228297. doi: 10.1371/journal.pone.0228297. eCollection 2020.
Prolonged periods of sedentary behavior are linked to cardiometabolic disease independent of exercise and physical activity. This study examined the effects of posture by comparing one day of sitting (14.4 ± 0.3 h) to one day of standing (12.2 ± 0.1 h) on postprandial metabolism the following day. Eighteen subjects (9 men, 9 women; 24 ± 1 y) completed two trials (sit or stand) in a crossover design. The day after prolonged sitting or standing the subjects completed a postprandial high fat/glucose tolerance test, during which blood and expired gas was collected immediately before and hourly for 6 h after the ingestion of the test meal. Indirect calorimetry was used to measure substrate oxidation while plasma samples were analyzed for triglyceride, glucose, and insulin concentrations. Standing resulted in a lower fasting plasma triglyceride concentration (p = 0.021) which was primarily responsible for an 11.3% reduction in total area under the curve (p = 0.022) compared to sitting. However, no difference between trials in incremental area under the curve for plasma triglycerides was detected (p>0.05). There were no differences in substrate oxidation, plasma glucose concentration, or plasma insulin concentration (all p>0.05). These data demonstrate that 12 h of standing compared to 14 h of sitting has a small effect the next day by lowering fasting plasma triglyceride concentration, and this contributed to a 11.3% reduction in postprandial plasma triglyceride total area under the curve (p = 0.022) compared to sitting.
久坐行为与代谢心血管疾病有关，与运动和体力活动无关。本研究通过比较一天坐姿（14.4±0.3 小时）和一天站姿（12.2±0.1 小时）对次日餐后代谢的影响来研究姿势的作用。18 名受试者（9 名男性，9 名女性；24±1 岁）以交叉设计完成了两项试验（坐或站）。在长时间坐姿或站姿后的第二天，受试者完成了餐后高脂肪/葡萄糖耐量试验，在此期间，在摄入试验餐前立即以及之后每小时收集一次血液和呼出气体。间接测热法用于测量底物氧化，同时分析血浆样本中的甘油三酯、葡萄糖和胰岛素浓度。与坐姿相比，站姿导致空腹血浆甘油三酯浓度降低（p=0.021），这主要导致总曲线下面积降低 11.3%（p=0.022）。然而，两次试验之间的血浆甘油三酯增量曲线下面积没有差异（p>0.05）。底物氧化、血浆葡萄糖浓度或血浆胰岛素浓度均无差异（均 p>0.05）。这些数据表明，与 14 小时坐姿相比，12 小时站立对次日的影响较小，通过降低空腹血浆甘油三酯浓度，餐后血浆甘油三酯总曲线下面积降低 11.3%（p=0.022）。
