Wang Y Z, Tan B Y, Li L, Li Z J
Department of Hematology, First Hospital of Lanzhou University, Lanzhou 730000, China.
Department of Laboratory, First Hospital of Lanzhou University, Lanzhou 730000, China.
Zhonghua Xue Ye Xue Za Zhi. 2020 Jan 14;41(1):59-63. doi: 10.3760/cma.j.issn.0253-2727.2020.01.011.
To explore the relationship between plasma coagulation factor XIII (FXIII) and bleeding events. A total of 55 cases of acute leukemia (AL) at the myelosuppression phase after chemotherapy hospitalized in our hospital from August 2017 to March 2018 were enrolled, with 35 normal controls. The concentration of plasma coagulation factor XIII (FXIII) was detected by ELISA to determine the relationship between the plasma FXIII levels in AL patients at the myelosuppression phase after chemotherapy with bleeding events. The level of FXIII in AL patients at the myelosuppression phase after chemotherapy was significantly lower than that in controls (<0.001) . The level of FXIII was inversely related with the bleeding severity (the Spearman correlation coefficient -0.761) . Given the diagnosis cut-off point of FXIII concentration as 103.9 μg/L, the sensitivity of diagnosing bleeding in AL patients at the myelosuppression phase after chemotherapy was 0.939, and the specificity 0.909. AL patients at the myelosuppression phase after chemotherapy had low level of plasma FXIII, and patients with lower plasma FXIII associated with higher incidence and severity of bleeding. FXIII level was an independent influencing factor of bleeding in AL patients at the myelosuppression phase after chemotherapy.
探讨血浆凝血因子 XIII（FXIII）与出血事件之间的关系。选取 2017 年 8 月至 2018 年 3 月在我院住院化疗后处于骨髓抑制期的 55 例急性白血病（AL）患者，并设 35 例正常对照。采用 ELISA 法检测血浆凝血因子 XIII（FXIII）浓度，以确定化疗后骨髓抑制期 AL 患者血浆 FXIII 水平与出血事件之间的关系。化疗后骨髓抑制期 AL 患者的 FXIII 水平显著低于对照组（<0.001）。FXIII 水平与出血严重程度呈负相关（Spearman 相关系数为 -0.761）。以 FXIII 浓度诊断切点为 103.9 μg/L 时，化疗后骨髓抑制期 AL 患者出血诊断的敏感度为 0.939，特异度为 0.909。化疗后骨髓抑制期 AL 患者血浆 FXIII 水平较低，血浆 FXIII 水平越低，出血发生率及严重程度越高。FXIII 水平是化疗后骨髓抑制期 AL 患者出血的独立影响因素。
