Chen Lin-Feng, Pan Ji-Chun, Feng Qian, Luo Yuan-Yuan, Yu Yang, Zhuang Yuan, Li Hui, Feng Yan-Nan, Wang De-Qing
Department of Transfusion, Chinese PLA General Hospital, Beijing 100853, China.
Department of Transfusion, Chinese PLA General Hospital, Beijing 100853, China. E-mail:
Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2015 Aug;23(4):1081-6. doi: 10.7534/j.issn.1009-2137.2015.04.034.
To investigate the factors influencing platelet transfusion results so as to improve the platelet transfusion efficiency.
According to the clinical symptoms (bleeding condition is stopped or improved)and the corrected count of increment (CCI), the patients were divided into efficient transfusion and inefficient transfusion groups. A total of 20 671 patients' clinical data and main platelet transfusion parameters in 26 045 tranfusions including platelet count of per- and post- transfusion, platelet component sorts, storage time and transfusion number were analysed.
The comparison of platelet transfusion efficiency in age and sex between two groups did not showed statistical difference (P > 0.05), the platelet count before transfusion between two groups showed statistical difference (t = -5.59, P < 0.001) after converting to log, a significant linear correlation did not exist between storage time of the platelet and CCI (corrected count of increment), but there was statistical difference in transfusion efficiency of patients with different diseases. The patients with hematologic diseases showed lower efficiency of platelet transfusion. According to the results of Wilcocon test detection, there was difference between different times of transfusion and transfusion efficiency, that is to say, the transfusion frequency was higher, the transfusion efficency was lower. The Fisher test indicated that the transfusion efficiency of single platelet transfusion was lower than that of transfussed platelet with other blood components (P < 0.01).
Platelet transfusion efficiency associates with many factors, including different diseases, whether being transfused with other blood components, the platelet count before transfusion, transfusion frequency, but the time of storage does not relate to the transfusion efficacy.
探讨影响血小板输注效果的因素，以提高血小板输注效率。
根据临床症状（出血情况停止或改善）及校正血小板增加值（CCI），将患者分为输注有效组和输注无效组。分析26045次输注中20671例患者的临床资料及主要血小板输注参数，包括输注前后血小板计数、血小板成分种类、储存时间及输注次数。
两组在年龄和性别方面的血小板输注效率比较无统计学差异（P>0.05），两组输注前血小板计数经对数转换后有统计学差异（t=-5.59，P<0.001），血小板储存时间与CCI（校正血小板增加值）之间不存在显著线性相关性，但不同疾病患者的输注效率有统计学差异。血液系统疾病患者的血小板输注效率较低。根据Wilcocon检验结果，不同输注次数与输注效率之间存在差异，即输注频率越高，输注效率越低。Fisher检验表明，单采血小板输注效率低于与其他血液成分同时输注的血小板（P<0.01）。
血小板输注效率与多种因素相关，包括不同疾病、是否与其他血液成分同时输注、输注前血小板计数、输注频率，但储存时间与输注疗效无关。
