多发性硬化症成人的体重指数与休闲时间体力活动之间的关联。
The Association between Body Mass Index and Leisure-Time Physical Activity in Adults with Multiple Sclerosis.
机构信息
Sports and Health Care Major, College of Humanities and Arts, Korea National University of Transportation, Chungju-si 27469, Korea.
Department of Physical Therapy, School of Health Professions, Sackler Faculty of Medicine, Tel-Aviv University, Tel Aviv, Ramat Aviv 6997801, Israel.
出版信息
Int J Environ Res Public Health. 2020 Feb 2;17(3):920. doi: 10.3390/ijerph17030920.
(1) Purpose: Conflicting information exists regarding the relationship between obesity, leisure-time physical activity (PA), and disability in people with multiple sclerosis (PwMS). We aimed to investigate the association between leisure-time PA and weight status in a relatively large cohort of PwMS. Furthermore, we examined this relationship according to the level of neurological disability. (2) Methods: The study included 238 PwMS (138 women) with a mean Expanded Disability Status Scale (EDSS) score of 2.5 (standard deviation [SD] = 1.7), mean disease duration of 6.4 (SD = 8.2) years, and mean age of 40.5 (SD = 12.9) years. Obesity was defined using two different metrics, each based on body mass index (BMI). Leisure-time PA was determined by the Godin-Shephard leisure-time PA questionnaire. Statistical analyses included multivariate logistic regression, the chi-square test, and Pearson coefficient correlations. (3) Results: The unadjusted odds ratio (OR) between leisure-time PA and BMI based on the World Health Organization's (WHO) definition was 1.070 ( = 0.844) for overweight and 1.648 ( = 0.254) for obesity. The adjusted OR was 1.126 ( = 0.763) for overweight and 1.093 ( = 0.847) for obesity after adjustment for age, gender, and disability status. Chi-square analysis revealed no significant correlation between leisure-time PA and obesity ( = 0.564) according to the BMI threshold for PwMS. The unadjusted OR (95% confidence interval [CI]) between disability level and BMI based on the WHO definition was 1.674 ( = 0.220) for overweight and 0.618 ( = 0.460) for obesity. The adjusted OR was 1.130 ( = 0.787) for overweight and 0.447 ( = 0.234) for obesity after adjustment for age, gender, and leisure-time PA. Similarly, chi-square analysis revealed no significant correlation between disability level and obesity ( = 0.701) per the BMI threshold for PwMS. (4) Conclusions: No association was found between leisure-time PA and BMI in PwMS. An additional finding was the absence of any association between obesity and neurological disability level in the multiple sclerosis cohort.
（1）目的：肥胖、休闲时间体力活动（PA）与多发性硬化症患者（PwMS）残疾之间的关系存在矛盾的信息。我们旨在调查相对较大的 PwMS 队列中休闲时间 PA 与体重状况之间的关联。此外，我们根据神经残疾水平检查了这种关系。（2）方法：该研究包括 238 名 PwMS（138 名女性），平均扩展残疾状况量表（EDSS）评分为 2.5（标准差[SD] = 1.7），平均疾病持续时间为 6.4 年（SD = 8.2），平均年龄为 40.5 岁（SD = 12.9）。肥胖使用两种不同的指标来定义，每个指标均基于体重指数（BMI）。休闲时间 PA 通过 Godin-Shephard 休闲时间 PA 问卷确定。统计分析包括多元逻辑回归、卡方检验和 Pearson 系数相关性。（3）结果：根据世界卫生组织（WHO）的定义，未调整的休闲时间 PA 与 BMI 之间的比值比（OR）为超重的 1.070（ = 0.844），肥胖的 1.648（ = 0.254）。调整后的 OR 为超重的 1.126（ = 0.763），肥胖的 1.093（ = 0.847），调整后纳入年龄、性别和残疾状况。根据 PwMS 的 BMI 阈值，卡方分析显示休闲时间 PA 与肥胖之间无显著相关性（ = 0.564）。根据 WHO 定义，残疾程度与 BMI 之间的未调整 OR（95%置信区间[CI]）为超重的 1.674（ = 0.220），肥胖的 0.618（ = 0.460）。调整后的 OR 为超重的 1.130（ = 0.787），肥胖的 0.447（ = 0.234），调整后纳入年龄、性别和休闲时间 PA。同样，根据 PwMS 的 BMI 阈值，卡方分析显示残疾程度与肥胖之间无显著相关性（ = 0.701）。（4）结论：在 PwMS 中，未发现休闲时间 PA 与 BMI 之间存在关联。另一个发现是在多发性硬化症队列中，肥胖与神经残疾水平之间没有任何关联。
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