Suh Junghwan, Choi Han Saem, Kwon Ahreum, Chae Hyun Wook, Kim Ho-Seong
Department of Pediatrics, Severance Children's Hospital, Endocrine Research Institute, Yonsei University College of Medicine, Seoul, Korea.
Clin Exp Pediatr. 2020 Apr;63(4):146-150. doi: 10.3345/cep.2019.00416. Epub 2019 Dec 6.
The incidence of precocious puberty has increased throughout the 20th century. The association between precocious puberty and endocrine disrupting chemicals including agricultural pesticides has been a subject of global study, but human data are lacking.
We investigated the relationship between agricultural pesticides and the development of precocious puberty.
We enrolled 60 female subjects at Severance Children's Hospital from December 2015 to January 2017. Of them, 30 were diagnosed with precocious puberty, while the other 30 prepubertal girls were enrolled as normal controls. We investigated their clinical characteristics and analyzed the urinary levels of 320 different agricultural pesticides.
Agricultural pesticide was detected in one of 30 patients with precocious puberty (3.3%) versus 2 of 30 girls in the normal control group (3.3% vs. 6.7%, P=0.554). Dinotefuran, a neonicotinoid-class insecticide, was detected in the samples of all 3 positive subjects.
Our results showed no relationship between agricultural pesticides and the development of precocious puberty. Larger sample sizes and robustly controlled variables are necessary to further investigate this topic.
整个20世纪，性早熟的发病率一直在上升。性早熟与包括农用杀虫剂在内的内分泌干扰化学物质之间的关联一直是全球研究的课题，但缺乏人体数据。
我们调查了农用杀虫剂与性早熟发展之间的关系。
2015年12月至2017年1月，我们在Severance儿童医院招募了60名女性受试者。其中，30名被诊断为性早熟，另外30名青春期前女孩作为正常对照入选。我们调查了她们的临床特征，并分析了320种不同农用杀虫剂的尿液水平。
30例性早熟患者中有1例检测到农用杀虫剂（3.3%），而正常对照组30名女孩中有2例检测到（3.3%对6.7%，P = 0.554）。所有3名阳性受试者的样本中均检测到新烟碱类杀虫剂呋虫胺。
我们的结果表明农用杀虫剂与性早熟的发展之间没有关系。需要更大的样本量和严格控制的变量来进一步研究这个课题。
