Buluş Ayşe Derya, Aşci Ali, Erkekoglu Pinar, Balci Aylin, Andiran Nesibe, Koçer-Gümüşel Belma
a The Ministry of Health, Keçiören Training and Research Hospital, Pediatric Endocrinology Clinics , Ankara , Turkey.
b Department of Pharmaceutical Toxicology , Faculty of Pharmacy, Hacettepe University , Ankara , Turkey , and.
Toxicol Mech Methods. 2016 Sep;26(7):493-500. doi: 10.3109/15376516.2016.1158894. Epub 2016 Jul 25.
Exposure to environmental chemicals can affect genetic and epigenetic molecular pathways and may cause altered growth and development. Among those exposures, endocrine-disrupting chemicals (EDCs) are of particular concern as humans are abundantly exposed to these chemicals by various means in every period of life. Several well-known environmental chemicals, including phthalates and bisphenol A (BPA), are classified as EDCs. These EDCs are suggested to play roles in early onset of puberty in girls. The aim of this study is to determine plasma phthalate (di(2-ethylhexyl)phthalate [DEHP] and its main metabolite mono(2-ethylhexyl)phthalate [MEHP]) and urinary BPA levels in girls with idiopathic central precocious puberty (CPP) and peripheral precocious puberty (PPP). This study was performed on newly diagnosed idiopathic central precocious puberty (CPP) patients (n = 42) and peripheral precocious puberty (PPP) (n = 42) patients, who were admitted to Keçiören Training and Research Hospital, Clinic of Pediatric Endocrinology between August 2012 and -July 2013. Nonobese healthy girls (n = 50) were used as the control group. Urinary BPA levels were not statistically different in control, PPP and CPP groups (medians 10.91, 10.63 and 10.15 μg/g creatinine, respectively; p > 0.05). Plasma DEHP levels were significantly higher in PPP group when compared to control. Plasma MEHP levels were not significantly different in control and PPP groups (p > 0.05). However, in CPP group, both plasma DEHP and MEHP levels were significantly higher than control and PPP groups. This study showed that phthalates might play a role in the occurence of CPP in girls.
接触环境化学物质会影响基因和表观遗传分子途径，并可能导致生长发育改变。在这些接触中，内分泌干扰化学物质（EDCs）尤其令人担忧，因为人类在生命的每个阶段都通过各种方式大量接触这些化学物质。几种知名的环境化学物质，包括邻苯二甲酸盐和双酚A（BPA），被归类为EDCs。这些EDCs被认为在女孩青春期早熟中起作用。本研究的目的是测定特发性中枢性性早熟（CPP）和外周性性早熟（PPP）女孩的血浆邻苯二甲酸盐（邻苯二甲酸二（2-乙基己基）酯[DEHP]及其主要代谢物单（2-乙基己基）邻苯二甲酸酯[MEHP]）和尿BPA水平。本研究对2012年8月至2013年7月期间入住凯奇奥伦培训与研究医院儿科内分泌科门诊的新诊断特发性中枢性性早熟（CPP）患者（n = 42）和外周性性早熟（PPP）患者（n = 42）进行。非肥胖健康女孩（n = 50）作为对照组。对照组、PPP组和CPP组的尿BPA水平无统计学差异（中位数分别为10.91、10.63和10.15μg/g肌酐；p>0.05）。与对照组相比，PPP组的血浆DEHP水平显著更高。对照组和PPP组的血浆MEHP水平无显著差异（p>0.05）。然而，在CPP组中，血浆DEHP和MEHP水平均显著高于对照组和PPP组。本研究表明，邻苯二甲酸盐可能在女孩CPP的发生中起作用。
