克里米亚-刚果出血热的诊断检测
Diagnostic Testing for Crimean-Congo Hemorrhagic Fever.
作者信息
Raabe Vanessa N
机构信息
Division of Infectious Diseases & Immunology, Department of Medicine, New York University Grossman School of Medicine, New York, New York, USA
Division of Pediatric Infectious Diseases, Department of Pediatrics, New York University Grossman School of Medicine, New York, New York, USA.
出版信息
J Clin Microbiol. 2020 Mar 25;58(4). doi: 10.1128/JCM.01580-19.
Abstract
Crimean-Congo hemorrhagic fever is the most geographically widespread tick-borne virus, with infection resulting in mortality in up to 30% of cases. Clinical diagnosis alone is difficult due to the nonspecific nature of symptoms; therefore, laboratory diagnostics should be utilized for patients with residence in or travel to regions of endemicity in whom the disease is suspected. This minireview provides an overview of laboratory tests available for Crimean-Congo hemorrhagic fever (CCHF) and their utility in diagnosis with a focus on diagnosing CCHF in humans.
摘要
克里米亚-刚果出血热是地理分布最广泛的蜱传病毒，感染导致高达30%的病例死亡。由于症状的非特异性，仅靠临床诊断困难；因此，对于居住在或前往流行地区且疑似感染该疾病的患者，应采用实验室诊断。本综述概述了可用于克里米亚-刚果出血热（CCHF）的实验室检测及其在诊断中的应用，重点是人类CCHF的诊断。
相似文献
1
Diagnostic Testing for Crimean-Congo Hemorrhagic Fever.克里米亚-刚果出血热的诊断检测
J Clin Microbiol. 2020 Mar 25;58(4). doi: 10.1128/JCM.01580-19.
2
Investigation of an isolated case of human Crimean-Congo hemorrhagic fever in Central Uganda, 2015.2015 年乌干达中部一起孤立的克里米亚-刚果出血热病例调查。
Int J Infect Dis. 2018 Mar;68:88-93. doi: 10.1016/j.ijid.2018.01.013. Epub 2018 Jan 31.
3
Diagnosis of Crimean-Congo hemorrhagic fever.克里米亚-刚果出血热的诊断。
Expert Rev Anti Infect Ther. 2015 May;13(5):555-66. doi: 10.1586/14787210.2015.1021782. Epub 2015 Mar 6.
4
Biosensor-based methods for Crimean-Congo hemorrhagic fever virus detection.基于生物传感器的克里米亚-刚果出血热病毒检测方法。
J Vector Borne Dis. 2021 Oct-Dec;58(4):383-385. doi: 10.4103/0972-9062.328976.
5
Crimean-Congo Hemorrhagic Fever in Migrant Worker Returning from Oman to India, 2016.2016年一名从阿曼返回印度的农民工感染克里米亚-刚果出血热
Emerg Infect Dis. 2017 Jun;23(6):1005-1008. doi: 10.3201/eid2306.161950.
6
Imported Crimean-Congo hemorrhagic Fever.输入性克里米亚-刚果出血热
J Clin Microbiol. 2005 Sep;43(9):4905-7. doi: 10.1128/JCM.43.9.4905-4907.2005.
7
Epidemiological characteristics, clinical and laboratory findings supporting preliminary diagnosis of Crimean-Congo hemorrhagic fever in an endemic region in Turkey.在土耳其的一个疫区，根据流行病学特征、临床和实验室检查结果，支持克里米亚-刚果出血热的初步诊断。
Wien Klin Wochenschr. 2020 Oct;132(19-20):581-588. doi: 10.1007/s00508-020-01719-5. Epub 2020 Aug 4.
8
Crimean-Congo Hemorrhagic Fever.克里米亚-刚果出血热
Lab Med. 2015 Summer;46(3):180-9. doi: 10.1309/LMN1P2FRZ7BKZSCO.
9
Evaluation of first rapid diagnostic kit for Anti-Crimean-Congo Hemorrhagic Fever virus IgM antibody using clinical samples from Iran.评价一种新型克里米亚-刚果出血热病毒 IgM 抗体快速诊断试剂盒在伊朗临床样本中的应用。
J Virol Methods. 2019 Mar;265:49-52. doi: 10.1016/j.jviromet.2018.12.015. Epub 2018 Dec 21.
10
Crimean-Congo hemorrhagic fever virus in livestock ticks and animal handler seroprevalence at an abattoir in Ghana.加纳一家屠宰场家畜蜱虫中的克里米亚-刚果出血热病毒及动物处理人员的血清阳性率
BMC Infect Dis. 2016 Jul 8;16:324. doi: 10.1186/s12879-016-1660-6.
引用本文的文献
1
Molecular and Clinical Characterization of Crimean-Congo Hemorrhagic Fever in Bulgaria, 2015-2024.2015 - 2024年保加利亚克里米亚-刚果出血热的分子与临床特征
Pathogens. 2025 Aug 6;14(8):785. doi: 10.3390/pathogens14080785.
2
Genetic Variations in Crimean-Congo Hemorrhagic Fever Virus: Challenges for Molecular Diagnostic Assays-A Case Report.克里米亚-刚果出血热病毒的基因变异：分子诊断检测面临的挑战——病例报告
Case Rep Infect Dis. 2025 Aug 5;2025:4600676. doi: 10.1155/crdi/4600676. eCollection 2025.
3
Crimean-Congo Hemorrhagic Fever Virus Infections in Slaughtered Camels and Abattoir Workers in the United Arab Emirates.阿拉伯联合酋长国屠宰骆驼及屠宰场工人中的克里米亚-刚果出血热病毒感染
Transbound Emerg Dis. 2025 May 8;2025:3409106. doi: 10.1155/tbed/3409106. eCollection 2025.
4
Circulation of tick-borne pathogens in wildlife of the Republic of Korea.韩国野生动物中蜱传病原体的传播
One Health. 2024 Oct 10;19:100913. doi: 10.1016/j.onehlt.2024.100913. eCollection 2024 Dec.
5
Can Wastewater Surveillance Enhance Genomic Tracking of Climate-Driven Pathogens?废水监测能否加强对气候驱动病原体的基因组追踪？
Microorganisms. 2025 Jan 28;13(2):294. doi: 10.3390/microorganisms13020294.
6
Crimean-Congo haemorrhagic fever (CCHF): present and future therapeutic armamentarium.克里米亚-刚果出血热（CCHF）：当前及未来的治疗手段
Infez Med. 2024 Dec 1;32(4):421-433. doi: 10.53854/liim-3204-2. eCollection 2024.
7
The Role of Nucleocapsid Protein (NP) in the Immunology of Crimean-Congo Hemorrhagic Fever Virus (CCHFV).核衣壳蛋白（NP）在克里米亚-刚果出血热病毒（CCHFV）免疫学中的作用。
Viruses. 2024 Sep 30;16(10):1547. doi: 10.3390/v16101547.
8
Crimean-Congo Hemorrhagic Fever Virus: An Emerging Threat in Europe with a Focus on Epidemiology in Spain.克里米亚-刚果出血热病毒：欧洲的一种新出现威胁，重点关注西班牙的流行病学情况。
Pathogens. 2024 Sep 6;13(9):770. doi: 10.3390/pathogens13090770.
9
Recent Advances in Crimean-Congo Hemorrhagic Fever Virus Detection, Treatment, and Vaccination: Overview of Current Status and Challenges.克里米亚-刚果出血热病毒检测、治疗及疫苗接种的最新进展：现状与挑战概述
Biol Proced Online. 2024 Jun 26;26(1):20. doi: 10.1186/s12575-024-00244-3.
10
Crimean-Congo Hemorrhagic Fever Virus for Clinicians-Diagnosis, Clinical Management, and Therapeutics.克里米亚-刚果出血热病毒临床医师诊疗手册：诊断、临床管理和治疗。
Emerg Infect Dis. 2024 May;30(5):864-873. doi: 10.3201/eid3005.231648.
本文引用的文献
1
Animal Models for Crimean-Congo Hemorrhagic Fever Human Disease.动物模型用于克里米亚-刚果出血热人类疾病。
Viruses. 2019 Jun 28;11(7):590. doi: 10.3390/v11070590.
2
Crimean-Congo hemorrhagic fever (CCHF) seroprevalence: A systematic review and meta-analysis.克里米亚-刚果出血热（CCHF）血清流行率：系统评价和荟萃分析。
Acta Trop. 2019 Aug;196:102-120. doi: 10.1016/j.actatropica.2019.05.019. Epub 2019 May 18.
3
Taxonomy of the order Bunyavirales: update 2019.布尼亚病毒目分类法：2019年更新
Arch Virol. 2019 Jul;164(7):1949-1965. doi: 10.1007/s00705-019-04253-6. Epub 2019 May 7.
4
Laboratory management of Crimean-Congo haemorrhagic fever virus infections: perspectives from two European networks.克里米亚-刚果出血热病毒感染的实验室管理：来自两个欧洲网络的观点。
Euro Surveill. 2019 Jan;24(5). doi: 10.2807/1560-7917.ES.2019.24.5.1800093.
5
Evaluation of first rapid diagnostic kit for Anti-Crimean-Congo Hemorrhagic Fever virus IgM antibody using clinical samples from Iran.评价一种新型克里米亚-刚果出血热病毒 IgM 抗体快速诊断试剂盒在伊朗临床样本中的应用。
J Virol Methods. 2019 Mar;265:49-52. doi: 10.1016/j.jviromet.2018.12.015. Epub 2018 Dec 21.
6
Ribavirin for treating Crimean Congo haemorrhagic fever.利巴韦林治疗克里米亚-刚果出血热
Cochrane Database Syst Rev. 2018 Jun 5;6(6):CD012713. doi: 10.1002/14651858.CD012713.pub2.
7
The Development of a Novel Diagnostic Assay That Utilizes a Pseudotyped Vesicular Stomatitis Virus for the Detection of Neutralizing Activity against Crimean-Congo Hemorrhagic Fever Virus.一种利用假型水疱性口炎病毒检测针对克里米亚-刚果出血热病毒中和活性的新型诊断检测方法的开发。
Jpn J Infect Dis. 2018 May 24;71(3):205-208. doi: 10.7883/yoken.JJID.2017.354. Epub 2018 Apr 27.
8
Sensitive and specific detection of Crimean-Congo Hemorrhagic Fever Virus (CCHFV)-Specific IgM and IgG antibodies in human sera using recombinant CCHFV nucleoprotein as antigen in μ-capture and IgG immune complex (IC) ELISA tests.采用重组克里米亚-刚果出血热病毒核蛋白作为抗原，通过 μ 捕获和 IgG 免疫复合物（IC）ELISA 试验，对人血清中克里米亚-刚果出血热病毒（CCHFV）特异性 IgM 和 IgG 抗体进行敏感和特异性检测。
PLoS Negl Trop Dis. 2018 Mar 26;12(3):e0006366. doi: 10.1371/journal.pntd.0006366. eCollection 2018 Mar.
9
A one-step multiplex real-time RT-PCR for the universal detection of all currently known CCHFV genotypes.一种一步法多重实时 RT-PCR 方法，用于通用检测所有目前已知的 CCHFV 基因型。
J Virol Methods. 2018 May;255:38-43. doi: 10.1016/j.jviromet.2018.01.013. Epub 2018 Jan 31.
10
Sequence Optimized Real-Time Reverse Transcription Polymerase Chain Reaction Assay for Detection of Crimean-Congo Hemorrhagic Fever Virus.用于检测克里米亚-刚果出血热病毒的序列优化实时逆转录聚合酶链反应检测法。
Am J Trop Med Hyg. 2018 Jan;98(1):211-215. doi: 10.4269/ajtmh.17-0165.
Zotero 插件