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本文引用的文献

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Animal Models for Crimean-Congo Hemorrhagic Fever Human Disease.动物模型用于克里米亚-刚果出血热人类疾病。
Viruses. 2019 Jun 28;11(7):590. doi: 10.3390/v11070590.
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Crimean-Congo hemorrhagic fever (CCHF) seroprevalence: A systematic review and meta-analysis.克里米亚-刚果出血热（CCHF）血清流行率：系统评价和荟萃分析。
Acta Trop. 2019 Aug;196:102-120. doi: 10.1016/j.actatropica.2019.05.019. Epub 2019 May 18.
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Taxonomy of the order Bunyavirales: update 2019.布尼亚病毒目分类法：2019年更新
Arch Virol. 2019 Jul;164(7):1949-1965. doi: 10.1007/s00705-019-04253-6. Epub 2019 May 7.
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Laboratory management of Crimean-Congo haemorrhagic fever virus infections: perspectives from two European networks.克里米亚-刚果出血热病毒感染的实验室管理：来自两个欧洲网络的观点。
Euro Surveill. 2019 Jan;24(5). doi: 10.2807/1560-7917.ES.2019.24.5.1800093.
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J Virol Methods. 2019 Mar;265:49-52. doi: 10.1016/j.jviromet.2018.12.015. Epub 2018 Dec 21.
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Ribavirin for treating Crimean Congo haemorrhagic fever.利巴韦林治疗克里米亚-刚果出血热
Cochrane Database Syst Rev. 2018 Jun 5;6(6):CD012713. doi: 10.1002/14651858.CD012713.pub2.
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The Development of a Novel Diagnostic Assay That Utilizes a Pseudotyped Vesicular Stomatitis Virus for the Detection of Neutralizing Activity against Crimean-Congo Hemorrhagic Fever Virus.一种利用假型水疱性口炎病毒检测针对克里米亚-刚果出血热病毒中和活性的新型诊断检测方法的开发。
Jpn J Infect Dis. 2018 May 24;71(3):205-208. doi: 10.7883/yoken.JJID.2017.354. Epub 2018 Apr 27.
8
Sensitive and specific detection of Crimean-Congo Hemorrhagic Fever Virus (CCHFV)-Specific IgM and IgG antibodies in human sera using recombinant CCHFV nucleoprotein as antigen in μ-capture and IgG immune complex (IC) ELISA tests.采用重组克里米亚-刚果出血热病毒核蛋白作为抗原，通过 μ 捕获和 IgG 免疫复合物（IC）ELISA 试验，对人血清中克里米亚-刚果出血热病毒（CCHFV）特异性 IgM 和 IgG 抗体进行敏感和特异性检测。
PLoS Negl Trop Dis. 2018 Mar 26;12(3):e0006366. doi: 10.1371/journal.pntd.0006366. eCollection 2018 Mar.
9
A one-step multiplex real-time RT-PCR for the universal detection of all currently known CCHFV genotypes.一种一步法多重实时 RT-PCR 方法，用于通用检测所有目前已知的 CCHFV 基因型。
J Virol Methods. 2018 May;255:38-43. doi: 10.1016/j.jviromet.2018.01.013. Epub 2018 Jan 31.
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Sequence Optimized Real-Time Reverse Transcription Polymerase Chain Reaction Assay for Detection of Crimean-Congo Hemorrhagic Fever Virus.用于检测克里米亚-刚果出血热病毒的序列优化实时逆转录聚合酶链反应检测法。
Am J Trop Med Hyg. 2018 Jan;98(1):211-215. doi: 10.4269/ajtmh.17-0165.

克里米亚-刚果出血热的诊断检测

Diagnostic Testing for Crimean-Congo Hemorrhagic Fever.

作者信息

Raabe Vanessa N

机构信息

Division of Infectious Diseases & Immunology, Department of Medicine, New York University Grossman School of Medicine, New York, New York, USA

Division of Pediatric Infectious Diseases, Department of Pediatrics, New York University Grossman School of Medicine, New York, New York, USA.

出版信息

J Clin Microbiol. 2020 Mar 25;58(4). doi: 10.1128/JCM.01580-19.

DOI:10.1128/JCM.01580-19
PMID:32024724
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7098759/
Abstract

Crimean-Congo hemorrhagic fever is the most geographically widespread tick-borne virus, with infection resulting in mortality in up to 30% of cases. Clinical diagnosis alone is difficult due to the nonspecific nature of symptoms; therefore, laboratory diagnostics should be utilized for patients with residence in or travel to regions of endemicity in whom the disease is suspected. This minireview provides an overview of laboratory tests available for Crimean-Congo hemorrhagic fever (CCHF) and their utility in diagnosis with a focus on diagnosing CCHF in humans.

摘要

克里米亚-刚果出血热是地理分布最广泛的蜱传病毒，感染导致高达30%的病例死亡。由于症状的非特异性，仅靠临床诊断困难；因此，对于居住在或前往流行地区且疑似感染该疾病的患者，应采用实验室诊断。本综述概述了可用于克里米亚-刚果出血热（CCHF）的实验室检测及其在诊断中的应用，重点是人类CCHF的诊断。