Hawkins B R, Higgins D A, Chan S L, Lowrie D B, Mitchison D A, Girling D J
Department of Pathology, University of Hong Kong, Queen Mary Hospital.
Am Rev Respir Dis. 1988 Dec;138(6):1616-21. doi: 10.1164/ajrccm/138.6.1616.
As part of a multifactorial study of the causes of breakdown to active tuberculosis of inactive pulmonary lesions, HLA-A, -B, and -DR typing was performed on 256 Hong Kong Chinese patients and 100 healthy control subjects. Patients were classified into those with smear-positive, active pulmonary tuberculosis (n = 103), those with inactive disease (n = 113), and those with breakdown to active disease after 6 months or more of inactivity (n = 40). Separately, 21 multiple-case families comprising 38 available parents and 93 offspring were examined for HLA haplotype segregation in relation to infection. Results of both studies indicate that among Hong Kong Chinese there is no statistically significant association between HLA and susceptibility to pulmonary tuberculosis.
作为对非活动性肺部病变发展为活动性肺结核病因的多因素研究的一部分，对256名中国香港患者和100名健康对照者进行了HLA - A、- B和 - DR分型。患者被分为痰涂片阳性的活动性肺结核患者（n = 103）、非活动性疾病患者（n = 113）以及在6个月或更长时间的非活动期后发展为活动性疾病的患者（n = 40）。另外，对21个多病例家庭进行了检查，这些家庭包括38名可获得的父母和93名后代，以研究与感染相关的HLA单倍型分离情况。两项研究结果均表明，在中国香港人群中，HLA与肺结核易感性之间不存在统计学上的显著关联。
