Vanhoutte P M
Department of Physiology and Biophysics, Mayo Clinic, Rochester, Minnesota 55905.
Am Rev Respir Dis. 1988 Dec;138(6 Pt 2):S24-30. doi: 10.1164/ajrccm/138.6_Pt_2.S24.
Damage to or dysfunction of respiratory epithelial cells may contribute to the etiology of bronchial hyperreactivity in asthma and airway infection. This brief overview summarizes the data, which suggest that release of relaxing factor(s) from epithelial cells may contribute to the regulation of bronchomotor tone. Reduced release of this epithelium-derived relaxing factor(s) may help to explain in part bronchial hyperreactivity secondary to epithelial damage.
呼吸道上皮细胞的损伤或功能障碍可能导致哮喘和气道感染中支气管高反应性的病因。本简要概述总结了相关数据，这些数据表明上皮细胞释放的舒张因子可能有助于调节支气管运动张力。这种上皮源性舒张因子释放减少可能部分解释继发于上皮损伤的支气管高反应性。
