Shidlovskyi Viktor O, Shidlovskyi Olexandr V, Tovkai Oleksandr A, Sheremet Michael I, Maksymyuk Vitaliy V, Tarabanchuk Volodimir V, Ivanovych Shved M, Heryak Mykolaivna S, Andreychyn Mykhailovych S, Hanberher Igorivna I, Piddubna Antonina A
Surgery Department, I. Horbachevsky Ternopil National Medical University, Ternopil, Ukraine.
Ukrainian Scientific and Practical Center of Endocrine Surgery, Endocrine and Tissue Transplantation of the Ministry of Health of Ukraine, Kyiv, Ukraine.
J Med Life. 2019 Oct-Dec;12(4):322-328. doi: 10.25122/jml-2019-0072.
Laboratory diagnosis of primary hyperaldosteronism is based on determining blood levels of aldosterone, renin on request, potassium, and sodium. The results of these studies are significantly influenced by drugs, preparation for the study and blood collection methods, age, gender, and concomitant diseases. The work analyzes the factors influencing the results of the study of aldosterone and identifies the main ways of their exclusion at each stage of the diagnosis. Their neglecting is the determining factor in obtaining false results, diagnostic errors, the selection of ill-treatment tactics, and inadequate treatment. All these diagnostic problems are covered in a variety of ways in the review, which is based on the analysis of results of individual authors' research and practical and clinical recommendations from leading world endocrinological associations. Results of laboratory diagnostics of PHA depend on the influence of many factors. Among them, it is essential to use different medication drugs, the rules for preparing for the study, and the method of conducting it. In assessing the results of research, it is necessary to take into account not only the indicators of the level of aldosterone in the blood but also the features of the clinical course of the disease, its compliance to the drug therapy, age, and gender of the patients.
原发性醛固酮增多症的实验室诊断基于测定醛固酮、按需测定的肾素、钾和钠的血液水平。这些研究结果受到药物、检查准备和采血方法、年龄、性别以及伴发疾病的显著影响。该研究分析了影响醛固酮研究结果的因素，并确定了在诊断的每个阶段排除这些因素的主要方法。忽视这些因素是获得错误结果、诊断失误、选择不当治疗策略以及治疗不足的决定性因素。本综述基于对个别作者研究结果以及世界主要内分泌协会的实践和临床建议的分析，以多种方式涵盖了所有这些诊断问题。原发性醛固酮增多症的实验室诊断结果取决于多种因素的影响。其中，使用不同的药物、检查准备规则以及检查实施方法至关重要。在评估研究结果时，不仅要考虑血液中醛固酮水平的指标，还要考虑疾病临床过程的特点、对药物治疗的依从性、患者的年龄和性别。
