Sugimoto Kenzaburou, Tokitou Rina, Kadosaki Mamoru, Takeuchi Mamoru
Department of Anesthesiology and Critical Care Medicine, Jichi Medical University, 3311-1, Yakushiji, Shimotsuke City, Tochigi, 329-0498, Japan.
JA Clin Rep. 2019 Feb 5;5(1):6. doi: 10.1186/s40981-019-0229-y.
Non-islet cell tumor producing insulin-like growth factor 2 involves hypoglycemia. During tumor resection, intense fluctuation of blood glucose level may occur. An artificial endocrine pancreas has been reported as beneficial for patients with insulinoma as it maintains stable glycemic levels, although scarcely described with insulin-like growth factor 2-releasing tumor.
An 84-year-old man had a recurrent left pleural solitary fibrous tumor releasing high molecular weight insulin-like growth factor 2 and experienced a frequent syncope accompanied by hypoglycemia. After anesthesia induction, an artificial endocrine pancreas, STG-55, was connected to the patient. Blood glucose level was stable at around 150 mg/dl during the resection surgery. The patient followed an uneventful course and was discharged without any complications.
An artificial endocrine pancreas may have the potential to stabilize the intraoperative blood glucose change in insulin-like growth factor 2-releasing tumor resection.
产生胰岛素样生长因子2的非胰岛细胞瘤会引发低血糖。在肿瘤切除过程中，血糖水平可能会出现剧烈波动。据报道，人工内分泌胰腺对胰岛素瘤患者有益，因为它能维持稳定的血糖水平，不过关于释放胰岛素样生长因子2的肿瘤的相关描述很少。
一名84岁男性患有复发性左胸腔孤立性纤维瘤，该肿瘤释放高分子量胰岛素样生长因子2，患者频繁晕厥并伴有低血糖。麻醉诱导后，将人工内分泌胰腺STG - 55与患者连接。在切除手术期间，血糖水平稳定在150mg/dl左右。患者术后恢复顺利，无任何并发症出院。
人工内分泌胰腺可能有潜力稳定胰岛素样生长因子2释放肿瘤切除术中的血糖变化。
