Center for Research and Training in Skin diseases and Leprosy, Tehran University of Medical Sciences, Tehran, Iran.
Iranian National Center for Addiction Studies, Tehran University of Medical Sciences, Tehran, Iran.
Lasers Med Sci. 2020 Jul;35(5):1007-1024. doi: 10.1007/s10103-020-02957-9. Epub 2020 Feb 5.
High-intensity focused ultrasound (HIFU) is widely used for skin rejuvenation and tightening. The aim of this study was to determine the safety and efficacy of HIFU for face and neck rejuvenation. A systematic search of peer reviewed articles published before December 2017 was performed using Medline, Web of Science, and Scopus databases. Retrieved studies were screened, and clinical trials or follow-up studies which were evaluated the effect of HIFU on rejuvenation treatments of face and neck area were included. Risk of bias for each study was assessed and was reported. Safety and efficacy variables, which were reported more often in papers, were included in meta-analysis. Seventeen studies involving 477 participants were included in the analysis. Meta-analysis showed moderate improvement as scores of 2.74 (95% CI 2.06-3.43) and 2.68 (95% CI 1.92-3.45), out of 5 maximum score, for objective improvement score and subjective satisfaction score, respectively. Meta-analysis of mean pain score, assessed by a 0-10 Likert score, was 4.2 (95% CI 4.27-5.19). Edema and erythema showed considerable heterogeneity, and no hyperpigmentation was reported by included studies. Included studies used multiple and different outcome variables with different scoring at various time points. Long follow-up was not reported by majority of studies. HIFU is safe procedure in short term and has a moderate effect on rejuvenation of face and neck areas.
高强度聚焦超声（HIFU）广泛用于皮肤年轻化和紧致。本研究旨在确定 HIFU 对面颈部年轻化的安全性和有效性。使用 Medline、Web of Science 和 Scopus 数据库对 2017 年 12 月之前发表的同行评议文章进行了系统检索。对检索到的研究进行筛选，纳入评估 HIFU 对面颈部年轻化治疗效果的临床试验或随访研究。评估了每个研究的偏倚风险，并进行了报告。安全性和有效性变量在论文中报告得更为频繁，被纳入荟萃分析。共有 17 项涉及 477 名参与者的研究纳入分析。荟萃分析显示，客观改善评分和主观满意度评分的得分为 5 分中的 2.74 分（95%CI 2.06-3.43）和 2.68 分（95%CI 1.92-3.45），分别为中度改善。采用 0-10 级 Likert 评分评估的平均疼痛评分的荟萃分析为 4.2（95%CI 4.27-5.19）。水肿和红斑显示出相当大的异质性，纳入的研究未报告色素沉着过度。纳入的研究使用了多种不同的结局变量，在不同的时间点使用不同的评分。大多数研究未报告长期随访情况。HIFU 在短期内是安全的，对面颈部年轻化有中度效果。
