Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada.
Physical Sciences Platform, Sunnybrook Research Institute, Toronto, Ontario, Canada.
NMR Biomed. 2020 Dec;33(12):e4253. doi: 10.1002/nbm.4253. Epub 2020 Feb 5.
To evaluate accelerated multi-contrast volumetric imaging with isotropic resolution reconstructed using low-rank and spatially varying edge-preserving constrained compressed sensing parallel imaging reconstruction (CP-LASER), for assessing infarct heterogeneity on post-infarction patients as a precursor to studies of utility for predicting ventricular arrhythmias.
Eleven patients with prior myocardial infarction were included in the study. All subjects underwent cardiovascular magnetic resonance (CMR) scans including conventional two-dimensional late gadolinium enhancement (2D LGE) and three-dimensional multi-contrast late enhancement (3D MCLE) post-contrast. The extent of the infarct core and peri-infarct gray zone of a limited mid-ventricular slab were derived respectively by analyzing MCLE images with an isotropic resolution of 2.2 mm and an anisotropic resolution of mm , and LGE images with a resolution of mm ; the respective measures across all subjects were statistically compared.
Using 3D MCLE, the infarct core size measured with isotropic resolution was similar to that measured with anisotropic resolution, while the peri-infarct gray zone size measured with isotropic resolution was smaller than that measured with anisotropic resolution ( , Cohen's ). Isotropic 3D MCLE yielded a significantly smaller measure of the peri-infarct gray zone size than conventional 2D LGE ( , Cohen's ). Overall, we have successfully shown the utility of isotropic 3D MCLE in a pilot patient study. Our results suggest that smaller voxels lead to more accurate differentiation between isotropic 3D MCLE-derived gray zone and core infarct because of diminished partial volume effect.
The CP-LASER accelerated 3D MCLE with isotropic resolution can be used in patients and yields excellent delineation of infarct and peri-infarct gray zone characteristics.
评估使用低秩和空间变化边缘保持约束压缩感知并行成像重建（CP-LASER）实现各向同性分辨率重建的加速多对比度容积成像，以评估梗死后患者的梗死异质性，作为研究其预测室性心律失常效用的前奏。
本研究纳入 11 例既往心肌梗死患者。所有患者均行心血管磁共振（CMR）扫描，包括常规二维晚期钆增强（2D LGE）和三维多对比度晚期增强（3D MCLE）后对比。通过分析具有各向同性分辨率为 2.2mm 和各向异性分辨率为 的 MCLE 图像，分别得出有限的中室壁段的梗死核心和梗死周边灰区的范围，用分辨率为 的 LGE 图像进行评估；对所有受试者的相应指标进行统计学比较。
使用 3D MCLE，各向同性分辨率测量的梗死核心大小与各向异性分辨率测量的结果相似，而各向同性分辨率测量的梗死周边灰区大小小于各向异性分辨率测量的结果（ ，Cohen's ）。各向同性 3D MCLE 得出的梗死周边灰区大小明显小于传统的 2D LGE（ ，Cohen's ）。总体而言，我们在初步患者研究中成功证明了各向同性 3D MCLE 的实用性。我们的结果表明，较小的体素导致各向同性 3D MCLE 衍生的灰区和核心梗死之间的区分更准确，因为部分容积效应减小。
CP-LASER 加速的各向同性分辨率 3D MCLE 可用于患者，并能很好地描绘梗死和梗死周边灰区特征。
