Department of Pharmaceutics, College of Pharmacy, University of Hafr Al Batin, Al Jamiah, Hafr Al Batin 39524, Saudi Arabia.
Department of Pharmaceutical Sciences & Technology, BIT, Mesra, Ranchi-835215, Jharkhand, India.
Curr Pharm Des. 2020;26(11):1167-1180. doi: 10.2174/1381612826666200206094529.
The contemporary drug discovery research shows that most of the drug candidates are highly potent, but showing poor aqueous solubility leads a variety of challenges for formulation scientists to develop a suitable formulation to improve the systemic bioavailability of such drugs. Lipid-based nanocarriers act as a major and most projecting approach overcoming the limitations which affect several physiochemical properties of drug such as the solubility, partition coefficient and bioavailability or absorption. This also fulfills a variety of product requirements and helps to overcome several limitations as decided by symptoms of the disease, various routes of administration of drug, price concern, increasing strength of product, noxious or harmful effect of drug, and dose efficacy. The lipidic nanosystem formulates aqueous drug in lipid base and is also a commercially feasible approach for the formulation of different dosage forms meant for topical or transdermal, oral, ocular, pulmonary, and parenteral delivery. This review provides a brief on lipid-based drug delivery nanocarrier and the mechanisms by which lipids and lipidic excipients improve the oral absorption of drugs with poor aqueous solubility and also provide a viewpoint on the promising applications of lipidic nanoparticulate systems.
当代药物发现研究表明，大多数候选药物具有很强的效力，但由于其水溶性差，给制剂科学家带来了各种挑战，需要开发合适的制剂来提高此类药物的全身生物利用度。基于脂质的纳米载体是克服影响药物多种物理化学性质（如溶解度、分配系数和生物利用度或吸收）的局限性的主要和最有前途的方法。这也满足了各种产品需求，并有助于克服由疾病症状、药物的各种给药途径、价格问题、产品强度增加、药物的毒性或有害作用以及剂量疗效决定的多种局限性。脂质纳米系统将水溶性药物制成脂质基质，并为不同剂型的制剂提供了一种商业上可行的方法，适用于局部或透皮、口服、眼部、肺部和肠胃外给药。本文简要介绍了基于脂质的药物传递纳米载体，以及脂质和脂质赋形剂改善水溶性差的药物口服吸收的机制，并对脂质纳米颗粒系统的有前途的应用提供了观点。
