Cancer Institute, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, 200032, People's Republic of China.
Shaanxi University of Chinese Medicine, Xianyang, 712046, People's Republic of China.
Int J Nanomedicine. 2022 Sep 14;17:4227-4259. doi: 10.2147/IJN.S377149. eCollection 2022.
10-Hydroxycamptothecin (HCPT) is a natural plant alkaloid from Camptotheca that shows potent antitumor activity by targeting intracellular topoisomerase I. However, factors such as instability of the lactone ring and insolubility in water have limited the clinical application of this drug. In recent years, unprecedented advances in biomedical nanotechnology have facilitated the development of nano drug delivery systems. It has been found that nanomedicine can significantly improve the stability and water solubility of HCPT. NanoMedicines with different diagnostic and therapeutic functions have been developed to significantly improve the anticancer effect of HCPT. In this paper, we collected reports on HCPT nanomedicines against tumors in the past decade. Based on current research advances, we dissected the current status and limitations of HCPT nanomedicines development and looked forward to future research directions.
10-羟基喜树碱（HCPT）是一种来源于喜树的天然植物生物碱，通过靶向细胞内拓扑异构酶 I 显示出强大的抗肿瘤活性。然而，内酯环的不稳定性和水中的不溶性等因素限制了该药物的临床应用。近年来，生物医学纳米技术的空前发展促进了纳米药物递送系统的发展。已经发现，纳米医学可以显著提高 HCPT 的稳定性和水溶性。已经开发出具有不同诊断和治疗功能的纳米药物，以显著提高 HCPT 的抗癌效果。在本文中，我们收集了过去十年中关于 HCPT 纳米药物治疗肿瘤的报告。基于当前的研究进展，我们剖析了 HCPT 纳米药物开发的现状和局限性，并展望了未来的研究方向。
