享乐性摄食对酒精摄入的行为和神经生物学后果。
Behavioral and Neurobiological Consequences of Hedonic Feeding on Alcohol Drinking.
机构信息
Department of Integrative Physiology and Neuroscience, Washington State University, Pullman, WA, United States.
Laboratory of Endocrine and Neuropsychiatric Disorders, Division of Basic Pharmaceutical Sciences, College of Pharmacy, Xavier University of Louisiana, New Orleans, LA, United States.
出版信息
Curr Pharm Des. 2020;26(20):2309-2315. doi: 10.2174/1381612826666200206092231.
A complex interplay of peripheral and central signaling mechanisms within the body of an organism maintains energy homeostasis. In addition, energy/food intake is modified by various external factors (e.g., palatability, food availability, social and environmental triggers). Highly palatable foods can provoke maladaptive feeding behavior, which in turn disrupts normal homeostatic regulation resulting in numerous health consequences. Furthermore, neuroendocrine peptides, traditionally considered to regulate appetite and energy homeostasis, also control the intake and reinforcing properties of alcohol and drugs of abuse. Therefore, dysregulated eating as a result of a hedonic/binge-like intake of hyper-palatable food may impact alcohol drinking behavior. Relevant in this case is the fact that eating disorders are highly comorbid with several neuropsychiatric conditions, including alcohol use disorder. The present review is intended to summarize the neurobiological and functional consequences of hedonic feeding on alcohol intake.
机体内部的外周和中枢信号机制的复杂相互作用维持着能量稳态。此外，能量/食物摄入还受到各种外部因素的影响（例如，美味度、食物可获得性、社交和环境诱因）。高美味度的食物会引发适应不良的进食行为，从而破坏正常的体内平衡调节，导致许多健康后果。此外，神经内分泌肽传统上被认为可以调节食欲和能量稳态，也可以控制酒精和滥用药物的摄入和强化作用。因此，由于享乐/暴食样摄入超美味食物而导致的饮食失调可能会影响饮酒行为。在这种情况下，相关的事实是，饮食失调与多种神经精神疾病高度共病，包括酒精使用障碍。本综述旨在总结享乐性进食对酒精摄入的神经生物学和功能后果。
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