Virus, Lifestyle and Genes, Danish Cancer Society Research Center, Copenhagen, Denmark.
Department of Gynecology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
Paediatr Perinat Epidemiol. 2020 Mar;34(2):114-121. doi: 10.1111/ppe.12653. Epub 2020 Feb 6.
Studies have shown that fertility treatment in mothers is associated with neurological problems in children. However, knowledge about any association between maternal use of fertility treatment and febrile seizures in children is lacking.
To determine whether maternal use of fertility treatment is associated with febrile seizures in children.
All liveborn children in Denmark during 1996-2012 (n = 1 065 901) were linked with the Danish Infertility Cohort and the Danish national registers and were followed from one year of age until the first episode of a febrile seizure, death, emigration, loss to follow-up, or end of follow-up (December 2015). Cox proportional hazard regression was used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) with adjustment for potential confounders.
Approximately 16% children (n = 172 140) were conceived by infertile women, and approximately 3% (n = 34 082) were diagnosed with febrile seizures during follow-up. Compared with children conceived by fertile women, children conceived following any fertility treatment (HR 1.11, 95% CI 1.06, 1.16), following specific fertility treatment, for example IVF (HR 1.15, 95% CI 1.05, 1.25), ICSI (HR 1.20, 95% CI 1.10, 1.32), and following fertility drugs (HR 1.06, 95% CI 1.00, 1.11) had slight increase in risk of febrile seizures, after adjusting for calendar year of birth, parental age, education, parity status, and maternal smoking during pregnancy. The associations were unchanged when children conceived naturally by infertile women were used as the reference group.
Children conceived following fertility treatment had slightly increased relative risk for febrile seizures.
研究表明，母亲的生育治疗与儿童的神经问题有关。然而，关于母亲使用生育治疗与儿童热性惊厥之间的任何关联，知之甚少。
确定母亲使用生育治疗是否与儿童热性惊厥有关。
将丹麦 1996 年至 2012 年期间所有活产婴儿（n=1065901）与丹麦不孕队列和丹麦国家登记处进行链接，并从一岁开始随访，直至出现首次热性惊厥、死亡、移民、失访或随访结束（2015 年 12 月）。使用 Cox 比例风险回归估计风险比（HR）和 95%置信区间（CI），并调整潜在混杂因素。
大约 16%的儿童（n=172140）是由不孕女性受孕的，大约 3%（n=34082）在随访期间被诊断为热性惊厥。与由生育能力正常的女性受孕的儿童相比，任何生育治疗（HR 1.11，95%CI 1.06，1.16）、特定生育治疗（如 IVF，HR 1.15，95%CI 1.05，1.25）、ICSI（HR 1.20，95%CI 1.10，1.32）和生育药物（HR 1.06，95%CI 1.00，1.11）后受孕的儿童，热性惊厥的风险略有增加，调整了出生年份、父母年龄、教育程度、产次和母亲怀孕期间吸烟情况。当将不孕女性自然受孕的儿童作为参考组时，关联保持不变。
接受生育治疗受孕的儿童热性惊厥的相对风险略有增加。
