队列简介：中国安徽母婴健康研究。

Cohort profile: Anhui Maternal-Child Health Study in China.

机构信息

Department of Obstetrics and Gynecology, The First Affiliated Hospital of Anhui Medical University, Hefei, China.

Faculty of Education, Health and Wellbeing, University of Wolverhampton, Wolverhampton, UK.

出版信息

BMJ Open. 2022 Jun 28;12(6):e060091. doi: 10.1136/bmjopen-2021-060091.

DOI:10.1136/bmjopen-2021-060091

PMID:35768099

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9240940/

Abstract

PURPOSE

The Anhui Maternal-Child Health Study (AMCHS) aims to examine determinants of reproduction, pregnancy and postpartum maternal and child health outcomes in Chinese women who received assisted reproductive technology (ART).

STUDY DESIGN AND PARTICIPANTS

AMCHS is an ongoing cohort study starting from May 2017. AMCHS recruits participants from all couples who sought ART treatment in the First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China. The participants are interviewed to document baseline sociodemography, lifestyles, dietary intake and environmental exposure. Their clinical characteristics are obtained from hospital records. Samples of blood, follicular fluid and semen are collected at the clinic. Participants receive a standard long pituitary downregulation or a short protocol with an antagonist for the treatment. They are followed up from preconception to delivery, or discontinuation of ART treatment. Details of their children's health are documented through a questionnaire focusing on developmental status and anthropometry measurement.

FINDINGS TO DATE

Until April 2021, AMCHS had recruited 2042 couples in the study. 111 women withdrew from the study and 19 failed to retrieve oocytes. Among the 1475 confirmed pregnancies, 146 had miscarriages or terminated their pregnancies, 9 had stillbirths and 263 were ongoing pregnancies. The implantation failure increased with maternal age; adjusted OR was 1.43 (95% CI 1.16 to 1.77) in the age of 31-35 years, 1.97 (95% CI 1.46 to 2.66) in 35-39 years and 6.52 (95% CI 3.35 to 12.68) in ≥40 years compared with those aged 20-30 years. Among the 1057 couples with successful ART who were followed up for delivering babies, 576 had their children examined at age 30-42 days, 459 at 6 months and 375 at 12 months.

FUTURE PLANS

The AMCHS will identify comprehensive risk factors for poor ART outcomes and explore potential interaction effects of multiple factors including sociopsychological aspects of environmental exposure, dietary intake and genetics on maternal and child health.

摘要

目的

安徽母婴健康研究（AMCHS）旨在研究接受辅助生殖技术（ART）的中国女性生殖、妊娠和产后母婴健康结果的决定因素。

研究设计和参与者

AMCHS 是一项从 2017 年 5 月开始的正在进行的队列研究。AMCHS 招募了所有在安徽医科大学第一附属医院寻求 ART 治疗的夫妇的参与者。对参与者进行访谈以记录基线社会人口统计学、生活方式、饮食摄入和环境暴露情况。他们的临床特征从医院记录中获得。在诊所采集血液、卵泡液和精液样本。参与者接受标准的长垂体下调或拮抗剂短方案进行治疗。从受孕前到分娩或 ART 治疗终止，对他们进行随访。通过关注发育状况和人体测量学测量的问卷记录他们孩子的健康详细信息。

目前的发现

截至 2021 年 4 月，AMCHS 已在研究中招募了 2042 对夫妇。111 名女性退出了研究，19 名女性未能取出卵子。在 1475 例确认的妊娠中，146 例流产或终止妊娠，9 例死产，263 例妊娠仍在继续。随着母亲年龄的增长，着床失败率增加；调整后的 OR 为 31-35 岁时为 1.43（95%CI 1.16-1.77），35-39 岁时为 1.97（95%CI 1.46-2.66），≥40 岁时为 6.52（95%CI 3.35-12.68）与 20-30 岁年龄组相比。在 1057 对成功进行 ART 并随访分娩婴儿的夫妇中，576 对夫妇的孩子在 30-42 天龄时接受检查，459 对在 6 个月龄时接受检查，375 对在 12 个月龄时接受检查。