Yuan Li-Li, Wang Fang, Chen Xue, Zhang Yang, Zhang Jian-Ping, Yang Jun-Fang, Ding Juan, Zhen Cheng-Liang, Wang Meng-Nan, Chen Dan-Na, Han Lu-You, Li Pei-Yu, He Yuan-Li, Liu Hong-Xing
Department of Pathology & Laboratorial Medicine, Hebei Yanda LU Dao-Pei Hospital, Langfang 065201, Hebei Province, China.
Department of Bone Marrow Transplantation, Hebei Yanda LU Dao-Pei Hospital, Langfang 065201, Hebei Province, China.
Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2020 Feb;28(1):314-319. doi: 10.19746/j.cnki.issn.1009-2137.2020.01.052.
To study the epidemiologic characteristics of human herpes virus (HHV) activated infection in the diseases of blood system and patients received allo-HSCT by statistically analyzing the screening results of 8 human herpes viruses (HHVs) of 4164 patients in Hebei Yanda LU Dao-Pei Hospital from 2012 to 2017.
PCR was used to screen 8 HHVs.
Two thousand and fifty-two patients (49.28%) were HHV-positive among 4164 patients screened. Among these patients screened, the infection spectra of 8 human HHVs in hematological diseases as well as patients received allogeneic hematopoietic stem cell transplantation of totally 2994 patients were summarized as follows: the positive rate of EBV (29.49%) was the highest, that of HCMV (23.15%), HHV-6 was 18.77% and HHV-7 was 17.64%, while the remaining 4 HHVs all≤2.1%. The rate of co-infection of various HHVs was significantly higher than that of single infection of HHV among all these disease groups except familial hemophagocytic lymphohistiocytosis, for which single EBV infection was the most common. The differences of positive rates among these 8 human HHVs in hematological diseases as well as patients received allogeneic hematopoietic stem cell transplantation were statistically significant by Chi-square test of R*C tables (χ=54.99, P＜0.05). For each HHV, the differences of positive rates among the above-mentioned disease groups were also statistically significant except HHV-8 (P＜0.05).
The patients with various blood diseases have different activated infection spectra of HHVs. EBV, HCMV, HHV-6 and HHV-7 are most common in HHVs infection. Different HHVs infections correlate with different hematologion diseases.
通过对河北燕达陆道培医院2012年至2017年4164例患者的8种人类疱疹病毒（HHV）筛查结果进行统计分析，研究血液系统疾病及接受异基因造血干细胞移植（allo-HSCT）患者中人类疱疹病毒激活感染的流行病学特征。
采用聚合酶链反应（PCR）法筛查8种HHV。
在4164例筛查患者中，2052例（49.28%）HHV阳性。在这些筛查患者中，对总共2994例血液系统疾病及接受异基因造血干细胞移植患者的8种人类HHV感染谱总结如下：EB病毒（EBV）阳性率最高（29.49%），其次是巨细胞病毒（HCMV，23.15%）、HHV-6为18.77%、HHV-7为17.64%，其余4种HHV均≤2.1%。除家族性噬血细胞性淋巴组织细胞增生症外，各疾病组中各种HHV的合并感染率均显著高于HHV单一感染率，其中单一EBV感染最为常见。通过R*C表的卡方检验（χ=54.99，P＜0.05），这8种人类HHV在血液系统疾病及接受异基因造血干细胞移植患者中的阳性率差异有统计学意义。对于每种HHV，除HHV-8外，上述疾病组间的阳性率差异也有统计学意义（P＜0.05）。
不同血液系统疾病患者的HHV激活感染谱不同。EBV、HCMV、HHV-6和HHV-7是HHV感染中最常见的。不同的HHV感染与不同的血液系统疾病相关。
