Department of Chemistry, Birla Institute of Technology-Mesra, Ranchi 835215, Jharkhand, India.
Department of Chemistry, Birla Institute of Technology-Mesra, Ranchi 835215, Jharkhand, India.
Int J Biol Macromol. 2020 Apr 15;149:908-920. doi: 10.1016/j.ijbiomac.2020.02.009. Epub 2020 Feb 3.
Polyacrylamide graft Jhingan gum (Jh-g-PAMs) was synthesized adopting microwave assisted graft co-polymerization technique. The synthesized graft copolymer was characterized by various analytical techniques such as Elemental analysis, FTIR, TGA, XRD and NMR. Following standard protocol, drug matrix tablets using 5-Aminosalicylic Acid (5-ASA) were prepared and swelling and erosion studies were carried out in different pH dissolution media. The result revealed that maximum swelling and erosion took place in pH 7.4 while the lowest was recorded in pH 1.2. The 'in vitro' drug release studies revealed that grades with higher grafting % exhibited more sustained release. The highest sustained release was observed in Jh-g-PAM 3 (%G 1231) in pH 1.2 while the least was observed in native gum in pH 7.4. Furthermore, the kinetic studies revealed that 'n' values in all dissolution media lies within 0.5-1.0 which suggested non-Fickian diffusion mode of release. From the above results, it can be said that controlled release of 5-ASA using graft material was successful and hence it can be explored for treatment of colon related diseases.
采用微波辅助接枝共聚技术合成了聚丙烯酰胺接枝 Jhingan 胶（Jh-g-PAMs）。合成的接枝共聚物通过元素分析、FTIR、TGA、XRD 和 NMR 等各种分析技术进行了表征。根据标准方案，使用 5-氨基水杨酸（5-ASA）制备了药物基质片，并在不同 pH 溶解介质中进行了溶胀和侵蚀研究。结果表明，在 pH 7.4 时，最大的溶胀和侵蚀发生，而在 pH 1.2 时，最小。体外药物释放研究表明，具有较高接枝百分比的级分表现出更持续的释放。在 pH 1.2 时，Jh-g-PAM 3（%G 1231）表现出最高的持续释放，而在 pH 7.4 时，天然胶表现出最低的持续释放。此外，动力学研究表明，所有溶解介质中的“n”值均在 0.5-1.0 之间，表明释放遵循非 Fickian 扩散模式。从上述结果可以得出结论，使用接枝材料成功实现了 5-ASA 的控制释放，因此可以探索其用于治疗结肠相关疾病。
