Wu Qiong, Li Yan, Tang Li, Wu Li-An, Wang Cong-Yi
Cataract Intraocular Lens Center of the Fourth Hospital in Xi'an, Shaanxi Province, China.
Medicine (Baltimore). 2020 Feb;99(6):e19030. doi: 10.1097/MD.0000000000019030.
This study aimed to assess the efficacy of rigid versus foldable iris-fixed phakic intraocular lens (PIOL) implantation in the treatment of high myopia.
A systematic search based on electronic databases such as Pubmed, Embase, and Cochrane Library was conducted to identify relevant studies published up to January 11, 2019. The pooled odds ratios and weighted mean differences (WMDs) with corresponding 95% confidence intervals were calculated.
Eight comparative studies with 835 participants were included in this meta-analysis. The overall WMD showed statistical significance in terms of postoperative uncorrected distance visual acuity (UDVA), mean postoperative spherical equivalence (SE), and mean postoperative intraocular higher-order aberrations (HOA) (μm) for a 6-mm pupil, suggesting that foldable PIOL group showed significant improvement of high myopia, compared to rigid PIOL group. Besides, compared with rigid PIOL group, foldable PIOL group had beneficial effect on the proportion of eyes with central endothelial cell density (ECD) loss in patients with high myopia.
This meta-analysis provided the up-to-date evidence and found that foldable PIOL group had significant beneficial effect on UDVA, SE, HOA, contrast sensitivity, and ECD, except best spectacle-corrected visual acuity, and safety in the treatment of high myopia over rigid PIOL group.
本研究旨在评估硬性与可折叠式虹膜固定型有晶体眼人工晶状体（PIOL）植入术治疗高度近视的疗效。
基于电子数据库（如Pubmed、Embase和Cochrane图书馆）进行系统检索，以识别截至2019年1月11日发表的相关研究。计算合并比值比和加权平均差（WMD）及其相应的95%置信区间。
本荟萃分析纳入了8项比较研究，共835名参与者。总体WMD在术后裸眼远视力（UDVA）、术后平均球镜等效度（SE）以及6mm瞳孔下术后平均眼内高阶像差（HOA）（μm）方面显示出统计学意义，表明与硬性PIOL组相比，可折叠式PIOL组在高度近视治疗方面有显著改善。此外，与硬性PIOL组相比，可折叠式PIOL组对高度近视患者中央内皮细胞密度（ECD）损失眼的比例有有益影响。
本荟萃分析提供了最新证据，发现与硬性PIOL组相比，可折叠式PIOL组在治疗高度近视时，除最佳矫正视力外，在UDVA、SE、HOA、对比敏感度和ECD方面有显著有益影响，且安全性良好。
