State Key Laboratory of Precision Measurement Technology and Instruments, Department of Precision Instrument, Tsinghua University, 100084, Beijing, China.
PURSPEC Technologies, Inc, 33 Shuangqing Road, 100084, Beijing, China.
Anal Chim Acta. 2020 Mar 8;1101:74-80. doi: 10.1016/j.aca.2019.12.028. Epub 2019 Dec 13.
There is an increasing need for rapid and on-site detection of emerging drugs of abuse. In this work, we developed a method using a miniature dual-LIT (linear ion trap) mass spectrometer recently developed with comprehensive tandem mass spectrometry analysis capability, for qualitative and quantitative analysis of multiple drugs of abuse. Paper-capillary spray cartridges were used with related workflow established to simplify overall analysis procedure. Quantitation of ketamine and methamphetamine was achieved by beam-type collision-induced dissociation on the miniature dual-LIT mass spectrometer and a linear concentration range of 100-5000 ng/mL was obtained. The system has been applied in analysis of real urine samples from individuals addicted to morphine and methamphetamine use. The changes of the ratio of cocaine to its metabolite benzoylecgonine were also explored to estimate the time of cocaine intaking.
对于新兴滥用药物的快速现场检测的需求日益增长。在这项工作中，我们开发了一种方法，使用最近开发的具有全面串联质谱分析能力的微型双线性离子阱（linear ion trap）质谱仪，对多种滥用药物进行定性和定量分析。采用纸芯喷雾卡筒并建立相关工作流程以简化整体分析程序。在微型双线性离子阱质谱仪上通过束型碰撞诱导解离实现了氯胺酮和甲基苯丙胺的定量，线性浓度范围为 100-5000ng/mL。该系统已应用于分析来自吗啡和甲基苯丙胺成瘾个体的实际尿液样本。还探索了可卡因与其代谢物苯甲酰古柯碱的比值变化，以估计可卡因摄入的时间。
