School of Electronic and Information Engineering, Soochow University, Suzhou 215006, China.
College of Information Science & Electronic Engineering, Zhejiang University, Hangzhou 310027, China.
Molecules. 2022 May 30;27(11):3506. doi: 10.3390/molecules27113506.
As narcotic control has become worse in the past decade and the death toll of drug abuse hits a record high, there is an increasing demand for on-site rapid detection of illegal drugs. This work developed a portable digital linear ion trap mass spectrometer based on separate-region corona discharge ionization source to meet this need. A separate design of discharge and reaction regions was adopted with filter air as both carrier gas for the analyte and protection of the corona discharge needle. The linear ion trap was driven by a digital waveform with a low voltage (±100 V) to cover a mass range of 50-500 Da with a unit resolution at a scan rate of 10,000 Da/s. Eighteen representative drugs were analyzed, demonstrating excellent qualitative analysis capability. Tandem mass spectrometry (MS/MS) was also performed by ion isolation and collision-induced dissociation (CID) with air as a buffer gas. With cocaine as an example, over two orders of magnitude dynamic range and 10 pg of detection limit were achieved. A single analysis time of less than 10 s was obtained by comparing the information of characteristic ions and product ions with the built-in database. Analysis of a real-world sample further validated the feasibility of the instrument, with the results benchmarked by GC-MS. The developed system has powerful analytical capability without using consumables including solvent and inert gas, meeting the requirements of on-site rapid detection applications.
在过去十年中，麻醉药品管制情况恶化，滥用药物导致的死亡人数创下历史新高，因此对现场快速检测非法药物的需求日益增长。本工作开发了一种基于分区 corona 放电电离源的便携式数字线性离子阱质谱仪，以满足这一需求。采用放电区和反应区分开的设计，用过滤空气作为分析物的载气和 corona 放电针的保护气。线性离子阱由数字波形驱动，采用低电压（±100 V），在 10,000 Da/s 的扫描速率下，质量范围为 50-500 Da，分辨率为 1 个单位。分析了 18 种代表性药物，证明了其具有出色的定性分析能力。还通过离子隔离和碰撞诱导解离（CID）进行串联质谱（MS/MS）分析，以空气作为缓冲气体。以可卡因为例，实现了超过两个数量级的动态范围和 10 pg 的检测限。通过比较特征离子和产物离子的信息与内置数据库，不到 10 秒即可完成单次分析。对实际样品的分析进一步验证了仪器的可行性，其结果与 GC-MS 进行了基准测试。该系统具有强大的分析能力，无需使用溶剂和惰性气体等耗材，满足现场快速检测应用的要求。
