Messier C, Destrade C
UA C.N.R.S. 339, Université de Bordeaux I, Talence, France.
Behav Brain Res. 1988 Dec 1;31(2):185-91. doi: 10.1016/0166-4328(88)90022-8.
Previous experiments have shown that a post-training glucose injection can retroactively and non-contingently improve the retention of a previously learned association. To date, the memory-improving action of glucose has only been demonstrated in rats for negatively-motivated tasks. The present experiment sought to generalize these previous results by examining the effects in mice of post-training glucose injections on the retention of an operant bar-pressing response. The results show that post-training glucose can retroactively and non-contingently improve the retention of an appetitively motivated task in mice. There was a U-shaped relationship between the dose of glucose and the effect on memory similar to the ones already observed in rats using negatively motivated training. The implications of these results for an endogenous memory modulation mechanism are discussed.
先前的实验表明，训练后注射葡萄糖可以追溯性且非偶然性地提高对先前习得联想的记忆保持。迄今为止，葡萄糖改善记忆的作用仅在大鼠的负动机任务中得到证实。本实验旨在通过研究训练后注射葡萄糖对小鼠操作性压杆反应记忆保持的影响，来推广这些先前的结果。结果表明，训练后注射葡萄糖可以追溯性且非偶然性地提高小鼠对正动机任务的记忆保持。葡萄糖剂量与记忆效果之间呈U形关系，这与在大鼠负动机训练中观察到的情况相似。本文讨论了这些结果对内源性记忆调节机制的意义。
