酒精对肝脏脂质代谢的影响。
Alcohol effects on hepatic lipid metabolism.
机构信息
Division of Gastroenterology, University of Pennsylvania, Philadelphia, PA.
Division of Gastroenterology, University of Pennsylvania, Philadelphia, PA
出版信息
J Lipid Res. 2020 Apr;61(4):470-479. doi: 10.1194/jlr.R119000547. Epub 2020 Feb 6.
Abstract
Alcoholic liver disease (ALD) is the most prevalent type of chronic liver disease with significant morbidity and mortality worldwide. ALD begins with simple hepatic steatosis and progresses to alcoholic steatohepatitis, fibrosis, and cirrhosis. The severity of hepatic steatosis is highly associated with the development of later stages of ALD. This review explores the disturbances of alcohol-induced hepatic lipid metabolism through altered hepatic lipid uptake, de novo lipid synthesis, fatty acid oxidation, hepatic lipid export, and lipid droplet formation and catabolism. In addition, we review emerging data on the contributions of genetics and bioactive lipid metabolism in alcohol-induced hepatic lipid accumulation.
摘要
酒精性肝病 (ALD) 是全球最常见的慢性肝病，发病率和死亡率都很高。ALD 始于单纯性肝脂肪变性，然后进展为酒精性肝炎、肝纤维化和肝硬化。肝脂肪变性的严重程度与 ALD 后期阶段的发展高度相关。本综述探讨了通过改变肝脂质摄取、从头脂质合成、脂肪酸氧化、肝脂质输出以及脂质滴形成和分解代谢导致的酒精引起的肝脂质代谢紊乱。此外，我们还综述了遗传和生物活性脂质代谢在酒精引起的肝脂质堆积中的作用的最新数据。
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