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评估射血分数保留的肥厚型心肌病患者的右心室变形：一项 3.0T 心血管磁共振研究。

Assessing right ventricular deformation in hypertrophic cardiomyopathy patients with preserved right ventricular ejection fraction: a 3.0-T cardiovascular magnetic resonance study.

机构信息

Department of Radiology, West China Hospital, Sichuan University, Chengdu, Sichuan, China.

Department of Radiology, Key Laboratory of Obstetric & Gynecologic and Pediatric Diseases and Birth Defects of Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, China.

出版信息

Sci Rep. 2020 Feb 6;10(1):1967. doi: 10.1038/s41598-020-58775-0.

DOI:10.1038/s41598-020-58775-0
PMID:32029853
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7004999/
Abstract

To assess the global and regional right ventricular (RV) deformation in hypertrophic cardiomyopathy (HCM) patients with preserved right ventricular ejection fraction (RVEF) using 3.0-T cardiovascular magnetic resonance tissue tracking (CMR-TT). Eighty-two HCM patients and 32 age- and sex-matched healthy controls were enrolled. HCM patients were divided into groups depending on the presence or absence of right ventricular hypertrophy (RVH), RV late gadolinium enhancement (RV-LGE), and left ventricular outflow tract obstruction (LVOTO), respectively. The RV global and apical longitudinal peak strain (LPS) in HCM patients with RVH were significantly lower than that in HCM patients without RVH and controls (P < 0.05). The global, apical and mid-ventricular LPS in HCM patients with RV-LGE were significantly lower than that in HCM patients without RV-LGE and controls (P < 0.05). Lower LPS was demonstrated in HCM patients without RV-LGE compared with controls in apical and mid-ventricular levels (P < 0.05). No significant difference was found regarding global and regional LPS in HCM patients with LVOTO compared without LVOTO (all P > 0.05). CMR-TT was able to detect subclinical RV myocardial deformation prior to RVEF impairment, which was more severe in the presence of RVH and RV-LGE.

摘要

采用 3.0T 心血管磁共振组织追踪（CMR-TT）评估射血分数保留的肥厚型心肌病（HCM）患者的整体和局部右心室（RV）变形。纳入 82 例 HCM 患者和 32 名年龄和性别匹配的健康对照者。根据是否存在 RV 肥厚（RVH）、RV 晚期钆增强（RV-LGE）和左心室流出道梗阻（LVOTO），将 HCM 患者分为不同组。RVH 的 HCM 患者的 RV 整体和心尖纵向峰值应变（LPS）明显低于无 RVH 的 HCM 患者和对照组（P<0.05）。RV-LGE 的 HCM 患者的 RV 整体、心尖和中间心室 LPS 明显低于无 RV-LGE 的 HCM 患者和对照组（P<0.05）。与对照组相比，无 RV-LGE 的 HCM 患者在心尖和中间心室水平的 LPS 更低（P<0.05）。LVOTO 的 HCM 患者与无 LVOTO 的患者相比，在整体和局部 LPS 方面无显著差异（均 P>0.05）。CMR-TT 能够在 RVEF 受损之前检测到亚临床 RV 心肌变形，在存在 RVH 和 RV-LGE 时更为严重。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/499d/7004999/d6af82871578/41598_2020_58775_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/499d/7004999/4082f16f2bd2/41598_2020_58775_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/499d/7004999/7908b2b0954a/41598_2020_58775_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/499d/7004999/c6b4a23d46b9/41598_2020_58775_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/499d/7004999/d6af82871578/41598_2020_58775_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/499d/7004999/4082f16f2bd2/41598_2020_58775_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/499d/7004999/7908b2b0954a/41598_2020_58775_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/499d/7004999/c6b4a23d46b9/41598_2020_58775_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/499d/7004999/d6af82871578/41598_2020_58775_Fig4_HTML.jpg

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