Nava Tiago, Ansari Marc, Dalle Jean-Hugues, de Heredia Christina Diaz, Güngör Tayfun, Trigoso Eugenia, Falkenberg Ulrike, Bertaina Alice, Gibson Brenda, Jarisch Andrea, Balduzzi Adriana, Boenig Halvard, Krivan Gergely, Vettenranta Kim, Matic Toni, Buechner Jochen, Kalwak Krzysztof, Lawitschka Anita, Yesilipek Akif, Lucchini Giovanna, Peters Christina, Turkiewicz Dominik, Niinimäki Riitta, Diesch Tamara, Lehrnbecher Thomas, Sedlacek Petr, Hutt Daphna, Dalissier Arnaud, Wachowiak Jacek, Yaniv Isaac, Stein Jerry, Yalçin Koray, Sisinni Luisa, Deiana Marco, Ifversen Marianne, Kuhlen Michaela, Meisel Roland, Bakhtiar Shahrzad, Cesaro Simone, Willasch Andre, Corbacioglu Selim, Bader Peter
Division of Pediatric Hematology-Oncology, University Hospital of Geneva, Geneva, Switzerland.
Hematology and Immunology Department, Robert-Debre Hospital, Assistance Publique-Hopitaux de Paris & University of Paris, Paris, France.
Bone Marrow Transplant. 2020 Jun;55(6):1126-1136. doi: 10.1038/s41409-020-0818-4. Epub 2020 Feb 6.
Hematopoietic stem cell transplantation (HSCT) is currently the standard of care for many malignant and nonmalignant blood diseases. As several treatment-emerging acute toxicities are expected, optimal supportive measurements critically affect HSCT outcomes. The paucity of good clinical studies in supportive practices gives rise to the establishment of heterogeneous guidelines across the different centers, which hampers direct clinical comparison in multicentric studies. Aiming to harmonize the supportive care provided during the pediatric HSCT in Europe, the Pediatric Diseases Working Party (PDWP) of the European Society for Blood and Marrow Transplantation (EBMT) promoted dedicated workshops during the years 2017 and 2018. The present paper describes the resulting consensus on the management of sinusoidal obstructive syndrome, mucositis, enteral and parenteral nutrition, iron overload, and emesis during HSCT.
造血干细胞移植（HSCT）目前是许多恶性和非恶性血液疾病的标准治疗方法。由于预计会出现几种新出现的治疗相关急性毒性反应，最佳的支持性措施对HSCT的结果至关重要。支持性实践中高质量临床研究的匮乏导致不同中心制定了异质性的指南，这阻碍了多中心研究中的直接临床比较。为了协调欧洲儿科HSCT期间提供的支持性护理，欧洲血液和骨髓移植学会（EBMT）的儿科疾病工作组（PDWP）在2017年和2018年举办了专门的研讨会。本文描述了在HSCT期间关于窦性阻塞综合征、粘膜炎、肠内和肠外营养、铁过载和呕吐管理的最终共识。
