Abushaban Lulu, Rathinasamy Jebaraj, Sharma Prem N, Vel Mariappa Thinakar
Department of Pediatric Cardiology, Chest Diseases Hospital, Kuwait City, Kuwait.
Faculty of Medicine, Kuwait University, Kuwait City, Kuwait.
Ann Pediatr Cardiol. 2020 Jan-Mar;13(1):25-30. doi: 10.4103/apc.APC_171_18. Epub 2019 Oct 9.
The objective of this study is to establish normal reference ranges for the left ventricular mass (LVM) and LVM index (LVMI) in preterm infants according to the body surface area (BSA) and assess their correlation with body weight and gestational age.
In a prospective study, 268 preterm babies who fulfilled the criteria for inclusion were examined. Echocardiograms were performed to measure the LVM and LVMI on 0-6 day (s) of life and at weekly intervals until the babies reached 36 weeks. The preterm infants were divided into six groups according to their BSA: 0.07-0.08 m2, 0.09-0.10 m2, 0.11-0.12 m2, 0.13-0.14 m2, 0.15-0.16 m2, and 0.17-0.19 m2.
The mean gestational age was 29.8 (±2.38 standard deviation [SD]) weeks, ranging from 24 to 35 weeks. The mean body weight was 1479 (±413 SD) g, ranging from 588 to 3380 g, and the mean BSA was 0.13 m2, ranging from 0.07 to 0.19 m2. The LVM correlated well with the gestational age, body weight, and BSA. The LVMI correlated well with body weight and BSA. Reference ranges with the mean ± SD, range, and interquartile range were calculated for the LVM and LVMI according to the BSA. A significant gradual increase was observed in a LVM with increasing BSA. Overall, a progressive and significant increase in the LVM was observed during the first 9 weeks of life.
The LVM and LVMI exhibited a significant correlation with the BSA and body weight. This study provides reference data that can be used as a normal reference tool for the LVM and LVMI for preterm infants based on the BSA.
本研究的目的是根据体表面积（BSA）建立早产儿左心室质量（LVM）和左心室质量指数（LVMI）的正常参考范围，并评估它们与体重和胎龄的相关性。
在一项前瞻性研究中，对268名符合纳入标准的早产儿进行了检查。在出生后0至6天以及每周进行一次超声心动图检查，以测量LVM和LVMI，直至婴儿达到36周。根据BSA将早产儿分为六组：0.07 - 0.08平方米、0.09 - 0.10平方米、0.11 - 0.12平方米、0.13 - 0.14平方米、0.15 - 0.16平方米和0.17 - 0.19平方米。
平均胎龄为29.8（±2.38标准差[SD]）周，范围为24至35周。平均体重为1479（±413 SD）克，范围为588至3380克，平均BSA为0.13平方米，范围为0.07至0.19平方米。LVM与胎龄、体重和BSA密切相关。LVMI与体重和BSA密切相关。根据BSA计算了LVM和LVMI的参考范围，包括平均值±标准差、范围和四分位数间距。随着BSA的增加，LVM观察到显著的逐渐增加。总体而言，在出生后的前9周内，LVM观察到逐渐且显著的增加。
LVM和LVMI与BSA和体重表现出显著相关性。本研究提供了参考数据，可作为基于BSA的早产儿LVM和LVMI的正常参考工具。
